Table 6.
Univariate and multivariate logistic regression analyses for classification of prostate tumor vs normal prostate based on probe methylation
| Gene | Probe | Univariate p value | Univariate odds ratio | 95% confidence interval | Multivariate p value | Multivariate odds ratio | 95% confidence interval |
|---|---|---|---|---|---|---|---|
| ASB2 | cg01956154 | 3.48E−05*** | 0.3 | 0.17–0.53 | 0.72 | 1.46 | 0.18–11.84 |
| ASB2 | cg19949550 | 5.37E−11*** | 0.18 | 0.11–0.30 | 0.09 | 0.3 | 0.070–1.20 |
| ASB2 | cg09247392 | 4.42E−07*** | 0.09 | 0.04–0.24 | 0.18 | 0.12 | 0.010–2.60 |
| ETNK2 | cg20136584 | 4.89E−09*** | 16.64 | 6.49–42.68 | **0.0014 | 154.88 | 6.95–3449.78 |
| ETNK2 | cg21535580 | 6.27E−05*** | 3.17 | 1.80–5.59 | 0.08 | 19.76 | 0.70–559.54 |
| ETNK2 | cg00103329 | 1.09E−08*** | 8.27 | 4.01–17.07 | 0.26 | 11.95 | 0.15–933.7 |
| ETNK2 | cg01566404 | 1.38E−08*** | 5.69 | 3.12–10.36 | 0.17 | 0.09 | 0.00–2.78 |
| MEIS2 | cg01958086 | 1.12E−14*** | 2.85 | 2.19–3.72 | 0.73 | 0.81 | 0.24–2.70 |
| MEIS2 | cg03951374 | < 2.00E−16*** | 3.88 | 2.84–5.29 | 0.77 | 0.81 | 0.20–3.33 |
| MEIS2 | cg13800209 | 2.08E−12*** | 2.57 | 1.97–3.34 | 0.064 | 1.88 | 0.96–3.66 |
| MEIS2 | cg07433663 | < 2.00E−16*** | 2.35 | 1.92–2.88 | 0.46 | 0.75 | 0.35–1.60 |
| MEIS2 | cg21643314 | 8.79E−13*** | 3.77 | 2.62–5.43 | 0.71 | 0.79 | 0.23–2.72 |
| NRG1 | cg04773818 | 3.41E−14*** | 2.08 | 1.72–2.52 | 0.67 | 0.85 | 0.40–1.80 |
| NRG1 | cg04555373 | 3.96E−14*** | 3.18 | 2.35–4.28 | 0.071 | 4.67 | 0.88–24.94 |
| NRG1 | cg03430846 | 2.84E−14*** | 3.5 | 2.54–4.84 | 0.31 | 0.44 | 0.090–2.11 |
| NRG1 | cg24946597 | 2.41E−11*** | 2.82 | 2.08–3.83 | 0.81 | 0.9 | 0.37–2.16 |
| NRG1 | cg00614182 | 1.16E−13*** | 3.76 | 2.65–5.34 | *0.049 | 2.7 | 1.70–26.00 |
| NTN1 | cg14615768 | < 2.00E−16*** | 6.12 | 4.03–9.27 | 0.46 | 0.53 | 0.10–2.83 |
| NTN1 | cg17072465 | 0.000213*** | 3.25 | 1.74–6.08 | 0.36 | 0.32 | 0.030–3.71 |
| NUDT10 | cg21844331 | 0.14 | 1.37 | 0.90–2.09 | NA | NA | NA |
| NUDT10 | cg22363867 | 4.44E−07*** | 3.28 | 2.07–5.21 | 0.3 | 0.37 | 0.060–2.41 |
| NUDT10 | cg15159291 | 0.02* | 2.82 | 1.18–6.78 | 0.35 | 0.18 | 0.00–6.51 |
| NUDT10 | cg00648125 | 4.38E−05*** | 2.94 | 1.75–4.93 | 0.9 | 0.91 | 0.21–3.98 |
| NUDT10 | cg02975846 | 2.53E−05*** | 2.7 | 1.70–4.29 | 0.19 | 3.84 | 0.52–28.62 |
| NUDT10 | cg20430749 | 0.023* | 1.51 | 1.06–2.15 | 0.23 | 0.32 | 0.050–2.05 |
| NUDT10 | cg06481089 | 0.13 | 0.65 | 0.37–1.13 | NA | NA | NA |
| NUDT10 | cg09520583 | 6.25E−06*** | 6.47 | 2.88–14.55 | 0.2 | 2.72 | 0.58–12.76 |
| SRPX | cg16626088 | 2.13E−08*** | 26.69 | 8.46–84.23 | 0.99 | 1.01 | 0.090–11.53 |
| SRPX | cg14759284 | 4.31E−13*** | 6 | 3.70–9.74 | 0.98 | 0.99 | 0.30–3.24 |
| SRPX | cg19736094 | 6.00E−13*** | 5.11 | 3.44–7.58 | 0.57 | 0.62 | 0.12–3.14 |
| SRPX | cg17407511 | < 2.00E−16*** | 4.82 | 3.36–6.91 | 0.38 | 2.11 | 0.39–11.28 |
| SRPX | cg27485646 | 1.03E−11*** | 6.98 | 3.99–12.23 | 0.56 | 0.66 | 0.16–2.66 |
| SRPX | cg03509565 | 8.40E−13** | 8.04 | 4.54–14.23 | 0.073 | 5.25 | 0.85–32.27 |
Odds ratios and p values presented for methylation M values (logistic-transformed beta values)
Statistical significance indicated by asterisks: *0.01 < p < 0.05; ***p < 0.001