Table 4.
Functional and pathway enrichment analyses of upregulated genes in chronic periodontitis
| Category | Term | Genes | p-value | FDR (%) |
|---|---|---|---|---|
| GOTERM_BP_FAT | GO:0006955~immune response | CSF3, ITGAL, ST6GAL1, IGLV1–44, ENPP2, C3, TNFRSF17, SLAMF7, IGHM, CXCL12, CCL18, RGS1, FCGR2B, LAX1, FCN1, MS4A1, IL1B, IL2RG, CD79A, IGKC, FCGR3B, IGLC1 | 1.50E-12 | 2.31E-09 |
| GOTERM_BP_FAT | GO:0046649~lymphocyte activation | ITGAL, IKZF1, LAX1, MS4A1, IRF4, CD79A, SLAMF7, CXCL12 | 1.69E-05 | 0.025995389 |
| GOTERM_BP_FAT | GO:0001775~cell activation | ITGAL, IKZF1, LAX1, MS4A1, IRF4, CD79A, SLAMF7, ENTPD1, | 2.19E-05 | 0.033613816 |
| CXCL12 | ||||
| GOTERM_BP_FAT | GO:0006935~chemotaxis | PROK2, RAC2, ENPP2, FPR1, IL1B, CXCL12, CCL18 | 4.96E-05 | 0.07634361 |
| GOTERM_BP_FAT | GO:0042330~taxis | PROK2, RAC2, ENPP2, FPR1, IL1B, CXCL12, CCL18 | 4.96E-05 | 0.07634361 |
| GOTERM_BP_FAT | GO:0002684~positive regulation of immune system process | CD19, IKZF1, C3, LAX1, IL1B, IL2RG, CD79A, CXCL12 | 5.32E-05 | 0.081770006 |
| GOTERM_BP_FAT | GO:0045321~leukocyte activation | ITGAL, IKZF1, LAX1, MS4A1, IRF4, CD79A, SLAMF7, CXCL12 | 5.91E-05 | 0.090857027 |
| GOTERM_BP_FAT | GO:0048584~positive regulation of response to stimulus | CD19, C3, LAX1, IL1B, FABP4, CD79A, CXCL12 | 4.14E-04 | 0.635505695 |
| GOTERM_BP_FAT | GO:0007155~cell adhesion | ITGAL, SELL, ICAM2, ICAM3, PECAM1, COL15A1, NEDD9, | 5.28E-04 | 0.809495344 |
| CLDN10, SLAMF7, ENTPD1, CXCL12 | ||||
| GOTERM_BP_FAT | GO:0022610~biological adhesion | ITGAL, SELL, ICAM2, ICAM3, PECAM1, COL15A1, NEDD9, | 5.34E-04 | 0.818570769 |
| CLDN10, SLAMF7, ENTPD1, CXCL12 | ||||
| GOTERM_BP_FAT | GO:0007626~locomotory behavior | PROK2, RAC2, ENPP2, FPR1, IL1B, CXCL12, CCL18 | 9.08E-04 | 1.387461056 |
| GOTERM_BP_FAT | GO:0050863~regulation of T cell activation | IKZF1, LAX1, IL1B, IL2RG, IRF4 | 0.00138016 | 2.10243667 |
| GOTERM_BP_FAT | GO:0050778~positive regulation of immune response | CD19, C3, LAX1, IL1B, CD79A | 0.00301947 | 4.54592016 |
| GOTERM_BP_FAT | GO:0051249~regulation of lymphocyte activation | IKZF1, LAX1, IL1B, IL2RG, IRF4 | 0.00325016 | 4.885167435 |
| GOTERM_CC_FAT | GO:0005576~extracellular region | CSF3, COL4A2, ST6GAL1, COL4A1, IGLV1–44, ENPP2, C3, MMP7, CECR1, COL15A1, IGHM, CXCL12, CCL18, PROK2, FCN1, PECAM1, IL1B, FCRLA, IGKC, ENTPD1, FCGR3B, IGLC1, SRGN | 3.24E-04 | 0.37812111 |
| GOTERM_CC_FAT | GO:0044421~extracellular region part | CSF3, COL4A2, COL4A1, C3, MMP7, CECR1, COL15A1, CXCL12, CCL18, FCN1, PECAM1, IL1B, ENTPD1, SRGN | 5.83E-04 | 0.680822917 |
| GOTERM_MF_FAT | GO:0003823~antigen binding | IGLV1–44, FCN1, IGKC, IGHM, IGLC1 | 0.00152847 | 1.82616636 |
| KEGG_PATHWAY | hsa04060: Cytokine-cytokine receptor interaction |
CSF3, IL10RA, CSF2RB, IL1B, TNFRSF17, IL2RG, CXCL12, CCL18 | 0.00241736 | 2.314177036 |
| KEGG_PATHWAY | hsa04514: Cell adhesion molecules (CAMs) |
ITGAL, SELL, ICAM2, ICAM3, PECAM1, CLDN10 | 0.00244312 | 2.338574426 |
| KEGG_PATHWAY | hsa04640: Hematopoietic cell lineage |
CSF3, CD19, MS4A1, IL1B, MME | 0.00329177 | 3.139362079 |
GO Gene Ontology, BP Biological Process, CC Cellular Component, MF Molecular Function
KEGG Kyoto Encyclopedia of Genes and Genomes