Table 6.
Top 12 hub genes with higher degrees of connectivity in chronic periodontitis
| Gene symbol | Gene description | Degree | Connected genes |
|---|---|---|---|
| CD19 | CD19 molecule | 21 | C3, CD79A, CSF3, CXCL12, ENTPD1, FCGR2B, FCGR3B, FCRLA, ICAM3, IGLL5, IKZF1, IL10RA, IL1B, IL2RG, IL8, IRF4, ITGAL, MME, MS4A1, SELL, TNFRSF17 |
| IL8 | Interleukin 8 | 18 | C3, CCL18, CD19, CD79A, CSF3, CXCL12, FABP4, FCGR2B, FCGR3B, FPR1, ICAM3, IL1B, IL2RG, ITGAL, MME, MMP7, SELL, SRGN |
| CD79A | CD79a molecule | 16 | C3, CD19, CSF3, FCGR2B, FCGR3B, FCRLA, HCLS1, IGJ, IGLL5, IL1B, IL8, IRF4, MME, MS4A1, SEL, TNFRSF17 |
| FCGR3B | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | 14 | C3, CD19, CD79A, CSF3, CXCL12, ICAM3, IGLL5, IL10RA, IL1B, IL8, ITGAL, MME, SELL, SKAMF7 |
| SELL | Selectin L | 14 | CD19, CD79A, CHST2, CSF3, CXCL12, FCGR2B, FCGR3B, ICAM2, ICAM3, IKZF1, IL10RA, IL1B, IL8, ITGAL |
| CSF3 | Colony stimulating factor 3 | 13 | CD19, CD79A, CSF2RB, CXCL12, FCGR2B, FCGR3B, IL10RA, IL1B, IL2RG, IL8, MME, PROK2, SELL |
| IL1B | Interleukin 1 beta | 11 | C3, CD19, CD79A, CSF3, CXCL12, FCGR2B, FCGR3B, IL8, MMP7, SELL, SRGN |
| FCGR2B | Fc fragment of IgG, low affinity IIb, receptor (CD32) | 10 | C3, CD19, CD79A, CSF3, IGLL5, IL10RA, IL1B, IL8, ITGAL, SELL |
| CXCL12 | Chemokine (C-X-C motif) ligand 12 | 9 | C3, CCL18, CD19, CSF3, FCGR3B, FPR1, IL1B1, IL8, SELL |
| C3 | Complement component 3 | 8 | CD9, CD79A, CXCL12, FCGR2B, FCGR3B, FPR1, IL1B, IL8 |
| CD53 | CD53 molecule | 8 | CYTIP, EV12B, HCLS1, IL10RA, RAC2, SAMSN1, SRGN, THEMIS2 |
| IL10RA | Interleukin 10 receptor, alpha | 8 | CD19, CD53, CSF3, FCGR2B, FCGR3B, HCLS1, SELL, THEMIS2 |