Table 7.
Common molecular biomarker candidates for chronic periodontitis diagnosis, prognosis, and other processes
| Gene symbol | Gene description | Up- or Down-regulated Gene (p-value) | Biomarker applications |
|---|---|---|---|
| ALOX5 | arachidonate 5-lipoxygenase | upregulated gene (p < 0.01) | diagnosis, efficacy |
| APOC1 | apolipoprotein C1 | upregulated gene (p < 0.05) | prognosis, unspecified application |
| ARHGDIB | Rho GDP dissociation inhibitor beta | upregulated gene (p < 0.05) | diagnosis |
| BDNF | brain derived neurotrophic factor | downregulated gene (p < 0.01) | efficacy, response to therapy |
| CCL19 | C-C motif chemokine ligand 19 | upregulated gene (p < 0.01) | disease progression, unspecified application |
| CCR7 | C-C motif chemokine receptor 7 | upregulated gene (p < 0.05) | diagnosis, efficacy |
| CSF3 | colony stimulating factor 3 | upregulated gene (p < 0.05), logFc> 1 | diagnosis |
| CXCL12 | C-X-C motif chemokine ligand 12 | upregulated gene (p < 0.05), logFc> 1 | diagnosis, efficacy, prognosis, unspecified application |
| CXCR4 | C-X-C motif chemokine receptor 4 | upregulated gene (p < 0.05) | diagnosis |
| CYGB | cytoglobin | upregulated gene (p < 0.05) | diagnosis |
| EIF4E | eukaryotic translation initiation factor 4E | downregulated gene (p < 0.05) | prognosis |
| EREG | epiregulin | downregulated gene (p < 0.05) | prognosis, response to therapy |
| ESR1 | estrogen receptor 1 | upregulated gene (p < 0.01) | diagnosis, disease progression, efficacy, prognosis, response to therapy, unspecified application |
| IGH | immunoglobulin heavy locus | upregulated gene (p < 0.01) | diagnosis, prognosis |
| IL1B | interleukin 1 beta | upregulated gene (p < 0.05), logFc> 1 | diagnosis, efficacy, prognosis |
| KDR | kinase insert domain receptor | upregulated gene (p < 0.05) | disease progression, efficacy, prognosis, response to therapy, safety |
| LCK | LCK proto-oncogene, Src family tyrosine kinase | upregulated gene (p < 0.05) | diagnosis |
| LCP1 | lymphocyte cytosolic protein 1 | upregulated gene (p < 0.01) | disease progression |
| LGALS1 | galectin 1 | upregulated gene (p < 0.05) | diagnosis, prognosis |
| LYVE1 | lymphatic vessel endothelial hyaluronan receptor 1 | upregulated gene (p < 0.05) | disease progression |
| MMP9 | matrix metallopeptidase 9 | upregulated gene (p < 0.05) | diagnosis, disease progression, efficacy, prognosis, unspecified application |
| MS4A1 | membrane spanning 4-domains A1 | upregulated gene (p < 0.05), logFc> 1 | efficacy, prognosis, unspecified application |
| PAPPA | pappalysin 1 | upregulated gene (p < 0.05) | diagnosis |
| PDGFRB | platelet derived growth factor receptor beta | upregulated gene (p < 0.05) | prognosis, response to therapy, unspecified application |
| PECAM1 | platelet and endothelial cell adhesion molecule 1 | upregulated gene (p < 0.05), logFc> 1 | disease progression, efficacy, prognosis |
| PRKCB | protein kinase C beta | upregulated gene (p < 0.05) | diagnosis, efficacy, unspecified application |
| PTPRC | protein tyrosine phosphatase, receptor type C | upregulated gene (p < 0.01) | diagnosis, efficacy, unspecified application |
| SERPINA1 | serpin family A member 1 | upregulated gene (p < 0.01) | diagnosis, unspecified application |
| SFRP2 | secreted frizzled related protein 2 | upregulated gene (p < 0.05) | diagnosis |
| STRA6 | stimulated by retinoic acid 6 | upregulated gene (p < 0.05) | diagnosis |
| TAGLN | transgelin | upregulated gene (p < 0.01), logFc> 1 | diagnosis |
| TIMP4 | TIMP metallopeptidase inhibitor 4 | upregulated gene (p < 0.05) | diagnosis, prognosis |
| TNFSF13B | TNF superfamily member 13b | upregulated gene (p < 0.05) | efficacy, response to therapy |
| TPM1 | tropomyosin 1 | upregulated gene (p < 0.01) | diagnosis |
| VIM | vimentin | upregulated gene (p < 0.05) | diagnosis, efficacy, prognosis, unspecified application |