Table 8.

Upstream regulators of dominant biomarker candidates in chronic periodontitis

Dominant Biomarker Candidate	Upstream Regulator
CSF3	ABCG1,ADAM17,ANKRD42,ARNT,BIRC2,BIRC3,BMP4,C3AR1,C5,C5AR1,CARD9,CARM1,CD40,CEACAM1,CEBPA,CEBPB,CLEC4M,CLEC7A,CSF2,CTNNB1EP300,ETS2,EZH2,FGF2,FLI1,FOS,FOSL1GLI2,IFNG,IL10,IL15,IL17A,IL17F,IL17RA,IL1B,IL2,IL25,IL3,IL36GIL37,IL4,ITGB2JAK3,KRAS,KRT17,LECT2,LEP,LILRA2MAP3K8MYD88,NFKBIA,NFKBIE,NR1H2,OSM,PPARGPRDM1,PRKCE,PTGS2,RARA,RBPJ,SIRPA,SOCS1,STAT3,TCF4,TGM2,TLR2,TLR3,TLR4,TLR5,TLR9,TNF,TNFRSF1A,TNFRSF25,TNFSF11,TRAF6,VEGFA,WDR77,WNT5A
CXCL12	ACVRL1,ADAM10,APP,AR,BMP2,BSG,CCL11,CCR2,CCR5,CD14,CD40,CHUK,CREBBP,CSF3,CSF3R,CTNNB1,CXCL12,CXCR4,EBF1,EGFR,EPO,ERBB2,ERBB3,ERBB4,ESR1,ESR2,ETV5,F2R,FGF2,FHL2,GDF2,HIF1A,HMOX1,HRAS,IFNG,IFNGR1,IKBKB,IKBKG,IL10,IL15,IL17A,IL17RA,IL18,IL1A,IL1B,IL1R1,IL2,IL22,ITGA9,LTBR,MKL1,MMP1,MMP9,MYD88,NFKB2,NFKBIA,NQO1,OSM,PARP1,PRKAA1,PRKAA2,PRKCD,PTGS2,PTH,RARB,RBPJ,RELB,SNAI2,SP1,SPP1,TGFB1,TNC,TNF,TNFRSF1B,TRAF3,TWIST1,VCAN,VEGFA,VHL,WNT5A,YY1
IL1B	ABCG1,ACTN4,ADM,ADORA2B,AGER,AGT,AHR,AIMP1,ALB,ANKRD42,ANXA1,APOE,APP,ATF3,ATG7,B4GALNT1,BCL2,BCL2L1,BCL3,BCL6,BGN,BID,BIRC3,BMP7,BRAF,BRD2,BSG,BTG2,BTK,BTRC,C3,C3AR1,C5,C5AR1,C7,C9,CAMP,CARD9,CBL,CCL11,CCL2,CCL3,CCR2,CD14,CD200,CD28,CD36,CD40,CD40LG,CD44,CD69,CDK5R1,CEBPB,CEBPD,CHUK,CLEC10A,CLEC7A,CNR2,COCH,CR1L,CR2,CREB1,CRH,CSF1,CSF2,CST3,CTNNB1,CTSG,CXCL12,CXCL8,CYBB,CYP2J2,CYR61,DICER1,DUSP1,EGF,EGFR,EGLN1,ELANE,ELN,EPHX2,ERBB2,ESR1,ESR2,F2,F2R,F2RL1,F3,FAS,FASLG,FBXO32,FCGR2A,FGF2,FN1,FOSL1,FOXO1,GAS6,GHRHR,GLI2,GNRH1,HGF,HIF1A,HMOX1,HRAS,HSPD1,HTR7,ICAM1,IFNAR1,IFNB1,IFNG,IFNGR1,IGF1,IGFBP3,IGHM,IKBKB,IKBKG,IL10,IL10RA,IL11,IL12A,IL12B,IL13,IL17A,IL17RA,IL18,IL1A,IL1B,IL1R1,IL1RN,IL2,IL22,IL25,IL26,IL27,IL27RA,IL3,IL32,IL33,IL36A,IL36B,IL36RN,IL37,IL4,IL4R,IL6R,INSR,IRAK1,IRAK2,IRAK4,IRF3,IRF4,IRF6,IRF8,ITCH,ITGA4,ITGA5,ITGA9,ITGAM,ITGAX,ITGB1,ITGB3,JAG2,JAK2,JUN,KLF2,KNG1,KRAS,KRT17,LBP,LCN2,LECT2,LEP,LGALS1,LGALS9,LIF,LILRB4,LPL,LTA,LY6E,LYN,MAP 2 K3,MAP 3 K7,MAP 3 K8,MAPK12,MAPK14,MAPK7,MAPK8,MAPK9,MAPKAPK2,MEFV,MET,MIF,MTOR,MVP,MYD88,NCOR2,NFKB1,NFKBIA,NFKBIB,NLRC4,NOS1,NOS2,NR1H2,NR3C1,NR3C2,NT5E,OSM,P2RX4,PARP1,PDE5A,PDK2,PDPK1,PDX1,PELI1,PF4,PIK3R1,PIM3,PLA2G2D,PLAT,PLAU,PLG,PPARG,PRDM1,PRKCD,PRKCE,PROC,PSEN1,PTAFR,PTGER4,PTGES,PTGS2,PTPN6,PTX3,RAC1,RARB,RBPJ,RC3H1,RELA,RELB,RETNLB,RGS10,RHOA,RIPK1,RORA,RUNX3,S1PR3,SCD,SELP,SELPLG,SERPINE2,SFRP5,SFTPD,SGPP1,SIRT1,SMAD3,SMAD4,SMAD7,SMARCA4,SOCS1,SOCS6,SOD2,SP1,SPHK1,SPI1,SPP1,SREBF1,ST1,ST8SIA1,STAT1,STAT3,STK40,SYK,TAC1,TAC4,TARDBP,TCF3,TCL1A,TGFB1,TGFBR2,TGIF1,TGM2,THBD,TICAM1,TICAM2,TIRAP,TLR10,TLR2,TLR3,TLR4,TLR5,TLR6,TLR7,TLR9,TNC,TNF,TNFAIP3,TNFRSF1A,TNFRSF9,TNFSF10,TNFSF11,TNFSF12,TP63,TPSAB1/TPSB2,TRAF3,TRAF6,TREM1,TSC22D1,TSC22D3,TWIST1,TXN,TYROBP,UCN,VCAN,VEGFA,WNT5A,WT1,WWTR1,XDH,YY1,ZC3H12A,ZFP36
MS4A1	BCOR,GATA1,IL4,IRF4,IRF8,POU2F2,SPI1,TFE3,TGFB3,TXN
PECAM1	APLN,ATG7,CD44,CYR61,ENG,ERG,FAS,FGFR3,GATA1,GATA2,GATA6,HBB,HMOX1,IFNG,IL12A,IL17A,IL2,IL6,JAK2,KLF2,KLF4,KRAS,LEP,LIF,MAP 2 K1,MAPK14,MOG,MTOR,NAMPT,PIM3,PLCG1,PLG,PPARG,RELA,SOX2,SOX4,STAT1,STAT3,TGFA,TGFB1,TGFB2,THBD,TLR3,TNF,VEGFA,WT1
TAGLN	ACVRL1,ADAMTS12,APP,BMP2,BMP4,CREBBP,ELK1,ERBB2,F2R,FGF2,FHL2,FN1,FOXA1,FOXA2,GATA6,GNA15,HDAC1,HDAC3,HDAC4,HMGA1,HOXC8,HOXD3,HRAS,HTT,KLF4,MAPK14,MDK,MKL1,MKL2,MMP1,NOTCH1,PDLIM2,PPARG,RHOA,ROCK2,RUNX2,S1PR3,SMAD3,SMAD7,SMARCA2,SMARCA4,SP1,SP3,SPHK1,STAT3,TAZ,TGFB1,TGFB2,TGFB3,TGFBR2,TNF,TP63,VHL,YAP1,YY1