Fig. 5.

Structural connectivity matrices of fiber tracking. The matrices present the difference of fiber density between baseline and 8 weeks doxycycline treatment. Marked with a red box is the connectivity of motor cortex with various regions, particularly the white matter nodes, such as the anterior commissure, the internal capsule, and the thalamus, that also contribute to the corticospinal tract. A noticeable change of structural connectivity is also seen in the fimbria-fornix complex with most cortical nodes, contrasting a negative impact on the connections with the sensorimotor cortex and a positive increase for the connections with the cortical nodes that are associated with the default mode network