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. 2019 Feb 27;74:e658. doi: 10.6061/clinics/2019/e658

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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A: Immunohistochemical staining, B: Immunofluorescence staining

Immunoreactivity of VEGF proteins in Group 1 (control), Group 2 (vehicle), and Group 3 (melatonin). An increase in VEGF in the endothelial cells of the blood vessel (as indicated by yellow arrows) can be seen in the melatonin treatment group. Data are displayed as the mean ± S.E.M.; n=15 rats/group. **, p <0.05 indicates significance compared to the respective control values. *, p <0.05 indicates significance compared to the respective vehicle values.