Table 2. Association of CBS methylation and the risk of hypertension and stroke adjusted by multivariable logistic regression models.
| Hypertension | Stroke | |||
|---|---|---|---|---|
| Variable | OR | 95% CI | OR | 95% CI |
| CBS methylation | 1.035 | 1.025-1.045 | 1.015 | 1.003-1.028 |
| Gender (F/M) | 0.840 | 0.454-1.554 | 1.049 | 0.500-2.200 |
| Age (y) | 1.001 | 0.972-1.030 | 0.995 | 0.963-1.028 |
| Hcy (μmol/L) | 1.040 | 1.004-1.084 | 1.081 | 1.035-1.129 |
| UA (μmol/L) | 0.999 | 0.997-1.002 | 1.000 | 0.996-1.003 |
| TG (mmol/L) | 0.902 | 0.739-1.102 | 0.830 | 0.603-1.142 |
| TC (mmol/L) | 0.969 | 0.746-1.259 | 0.760 | 0.565-1.021 |
| BMI (kg/m2) | 1.071 | 0.964-1.190 | 0.969 | 0.929-1.011 |
| WC (cm) | 0.972 | 0.935-1.011 | 0.969 | 0.929-1.011 |
| HC (cm) | 1.034 | 1.003-1.066 | 1.017 | 0.980-1.055 |
| SBP (mmHg) | 1.051 | 1.032-1.071 | 1.051 | 1.026-1.077 |
| DBP (mmHg) | 1.039 | 1.014-1.065 | 1.017 | 0.984-1.051 |
| Glu (mmol/L) | 2.227 | 1.651-3.004 | 2.233 | 1.597-3.122 |
| Drinking (yes/no) | 0.708 | 0.499-1.003 | 0.369 | 0.220-0.618 |
| Smoking (yes/no) | 1.204 | 0.555-2.612 | 1.073 | 0.427-2.693 |
Hcy: plasma homocysteine, UA: uric acid, TG: triglycerides, TC: total cholesterol, BMI: body mass index, Glu: blood glucose, WC: waist circumference, HC: hip circumference, SBP: systolic blood pressure, DBP: diastolic blood pressure, PMR: percent of methylated reference, OR: odds ratios, 95% CI: 95% confidence intervals.