Table 1.
Characteristics of hormones and pituitary MRI in cases with ACTH deficiency
| Cases | Age/ sex | Cancer type | Abnormality of pituitary gland on MRI | ACTH | Cortisol | Decrease of other anterior pituitary hormones | References | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| TSH | LH | FSH | GH | PRL | |||||||
| 1 | 61/M | SCLC | No | (+) | (+) | (−) | (−) | (−) | (−) | (−) | Present case |
| 2 | 50/M | Melanoma | Mild enlargement of pituitary gland and thickening of stalk | (+) | (+) | (−) | (−) | (−) | (−) | (−) | 10 |
| 3 | 39/M | Melanoma | No | (+) | (+) | (−) | (−) | (−) | (−) | (−) | 18 |
| 4 | 50/F | Melanoma | No | (+) | (+) | (−) | (−) | (−) | (−) | (−) | 18 |
| 5 | 74/F | RCC | No | (+) | (+) | (−) | (−) | (−) | (−) | (−) | 19 |
| 6 | 55/M | Melanoma | No | (+) | (+) | (−) | (−) | (−) | (−) | (−) | 20 |
| 7 | 68/M | Melanoma | No | (+) | (+) | (−) | (−) | (−) | (−) | (−) | 20 |
| 8 | 50/M | Melanoma | No | (+) | (+) | (+) | (−) | (−) | (−) | (−) | 20 |
| 9 | 75/M | NSCLC | No | (+) | (+) | (−) | (−) | (−) | (−) | (−) | 20 |
| 10 | 63/F | NSCLC | Slightly thickened hypophyseal stalk | (+) | (+) | (−) | (−) | (−) | (−) | (−) | 21 |
| 11 | 54/M | RCC | Heterogeneous enhancement of pituitary gland and enlargement of basilar part | (+) | (+) | (−) | (−) | (−) | (−) | (−) | 22 |
Abbreviations: ACTH, adrenocorticotropic hormone; F, female; FSH, follicle-stimulating hormone; GH, growth hormone; LH, luteinizing hormone; M, male; NSCLC, non-small-cell lung cancer; PRL, prolactin; RCC, renal-cell carcinoma; SCLC, small-cell lung cancer; TSH, thyroid-stimulating hormone.