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. 2019 Mar 25;13:975–990. doi: 10.2147/DDDT.S195412

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Emodin treatment attenuated I/R-induced myocardial pyroptosis in vivo.

Notes: (A) Representative Western blot luminogram of GSDMD-FL and GSDMD-N among the sham, I/R, and I/R+Emodin (20 mg/kg) groups. (B) Protein semiquantification is shown for GSDMD-FL and GSDMD-N based on the results of 4A. (C) Concentrations of IL-1β in the serum were detected by ELISA. (D) Representative immunohistochemistry pictures in rat left ventricles. The protein level was standardized by GAPDH. Data are expressed as the mean ± SD. *P<0.05 vs the sham group, ^#P<0.05 vs the I/R group. Abbreviations: I/R, ischemia/reperfusion; GSDMD-FL, gasdermin D-full length; GSDMD-N, gasdermin D-N domain; ns, not significant.