Table 1. Probability of the 15 most common 3-atom combinations in rings in the first 1000 structures of the ZINC data set (“ZINC”), and in the 1000 structures generated by the GB-GM method using the ZINC probabilities (“GB-GM (62%)”) and a probability set where the probability of [*] [*]–[*] type bonding is increased to 80% (“GB-GM (80%)”).

Bonding	ZINC	GB-GM (62%)	GB-GM (80%)
C C–C	45%	41%	53%
C–C–C	15%	23%	21%
C–C–N	9%	9%	6%
C–N–C	6%	7%	5%
C C–N	4%	6%	4%
N C–C	3%	2%	2%
C N–C	2%	2%	1%
C–C–O	2%	2%	2%
N C–N	2%	0%	0%
C N–N	2%	0%	0%
C–O–C	1%	1%	1%
C–N–N	1%	1%	1%
C C–S	1%	1%	0%
C–S–C	1%	1%	1%
C C–O	1%	1%	1%