Fig. 2. SB2001, a HeLa cell-specific cytotoxic agent, and the identification of its target candidates. (a) The chemical structure of SB2001. (b) Cell viability after treatment with SB2001 for 2 days in HeLa and CaSki cells. Data are presented as the mean ± SEM (n = 2). (c) Target candidates from TS-FITGE and TPP in HeLa cells. Candidate proteins were prioritized according to the lethality ratio of HeLa cells over CaSki cells after the gene knockdown of each candidate protein.
