Table 3.
Symptoms included in articles by clinical content category
| Clinical content category | Representative symptom concepts |
|---|---|
| Pain | ache, pain, sore, tenderness; arm pain; back pain; breast pain; ear pain, ear ache; eye irritation; flank pain; general aches, general pain, body discomfort; hand pain; headache, head pain, head discomfort; kidney pain; knee pain; leg pain; neck-skull ache, neck-skull pain; rib pain; shoulder pain; sore throat; tooth ache |
| Fatigue and sleep disturbance | abnormal dreams, nightmares, vivid dreams; asthenia; disturbed sleep, insomnia; drowsiness; energy, lassitude, listlessness; exhaustion; fatigue; lethargic; sluggishness; somnolence; tiredness; weariness |
| Digestive system and abdomen | abdominal pain; abdominal cramp; anorexia, changes in appetite, hunger; bloating; constipation; difficulty swallowing; dry mouth; dyspepsia, heartburn, indigestion; epigastric pain; gastrointestinal upset, upset stomach; nausea; stomach ache, stomach pain; thirst |
| Affective mood | affect lability, emotional instability, emotional stories, emotional support; aggressiveness, snappy; agitated, irritable mood; altered mood, mood changes, mood swing; anger, frustration; apathy, loss of interest, indifference; bliss, elation, euphoria, happiness, joy, pleasure, warm fuzziness; calmness, relaxed; depressed mood, depression; down feelings, feeling low, melancholy, miserable, sadness; feeling empty; fussiness; hopelessness; self-confidence; stress; suicidal ideation |
| Perception | blackout; blind, blurred vision, diplopia, loss of vision, visual disturbances, visual distortions; burning, formication, neuropathy, numbness, pins and needles, paresthesia, sensation, tingling; dizziness, lightheadedness, head rush, head spinning, wooziness; |
| Affective anxiety | antsy, restlessness; anxiety; concern about the future; dread; fear; nervousness; panic, panic attacks; paranoia; worry |
| Circulatory and respiratory system | angina, chest pain, chest heaviness, chest tightness; breathless, difficulty breathing, dyspnea, short of breath; congestion, stuffy; heart flutter, heart racing, palpitation; hot flash; lung discomfort, lung hurt, lung irritation, lung pain; sinus pressure |
| Musculoskeletal system | arthralgia, joint pain, joint tenderness; clonus, dyskinesia, musclespasms; cramping legs, muscle cramp; debility, loss of strength, weakness; muscle aches, muscle pain, musculoskeletal discomfort, musculoskeletal pain, myalgia; stiffness |
| Cognitive function | amnesia, forgetful, memory impairment; brain fog; clean head, cloudy head, empty head, floaty head, lethargic head; cognitive difficulties, cognitive impairment; confusion; craving; daydreaming, difficulty concentrating, easily distracted, focus, short attention span; dazed; difficulty thinking, trouble thinking; dissociation; psychomotor agitation, psychomotor impairment; ear distortion, deafness, tinnitus; feeling high; feeling jittery; hallucinations, hearing things; tightness |
| Skin and subcutaneous tissue | irritation; itchiness, pruritus; skin discomfort |
| Genitourinary system | dysuria; sex drive, sexual inhibition, sexual urge; sexual dysfunction; urgent urination; vaginal dryness |
| General | chills; malaise |