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. Author manuscript; available in PMC: 2019 Mar 28.
Published in final edited form as: Nat Nanotechnol. 2010 Mar 7;5(4):302–309. doi: 10.1038/nnano.2010.24

Figure 1.

Figure 1

Nanotube sensing platform. a, A431 cell cultured on collagen-SWNT film. Zoom in on red circle: EGFR domains spanning the cell membrane. Domains I and III bind to EGF (red) and generate H2O2. b, NIR image of SWNT underneath A431 (left) and phase contrast image of A431 cell (right) cultured on SWNT sensors (658 nm excitation, 1mW, Alpha Plan-Apo 100x/1.46 oil emersion objective). c, Forward and reverse binding rate of SWNT sensor for various analytes show selectivity for H2O2. d, Fluorescence trace for control (no cells) show no steps. e, Trace for SWNT in the red circle in (b) show reversible, stepwise quenching (green trace), modeled by HMM (red).