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. 2019 Jan 24;10(1):140–154. doi: 10.1002/jcsm.12360

Figure 1.

Figure 1

Morphological and functional changes associated with cancer‐induced and chemotherapy‐induced cachexia. Body weight (BW) curves (A) and BW change (B) in vehicle‐treated animals (V), C26 hosts (CC), Folfiri‐treated mice (F), or Folfiri‐treated tumour bearers (CCF). Tumour size measured at sacrifice in CC and CCF groups (C). Gastrocnemius (GSN), tibialis anterior (TA), and quadriceps (Quad) muscle weights (D). Liver, spleen, and fat weights (E). All tissues and organs were normalized to the initial body weight (IBW) and expressed as weight/100 mg IBW. Whole body forelimb voluntary grasping strength, measured 13 days after tumour inoculation reported as peak force, was measured by taking advantage of a grip strength metre and expressed as the average of the three top pulls from each animal (F). Quantification of the cross‐sectional area (CSA) in TA and representative images obtained after immunofluorescence staining of TA muscle cross sections for laminin (red) (G). Data are expressed as means ± standard deviation. Statistical significance was evaluated by two‐way analysis of variance, and significant differences (at least P < 0.05) were reported as a P vs. V; b P vs. CC; c P vs. F.