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. 2019 Jan 24;10(1):140–154. doi: 10.1002/jcsm.12360

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© 2019 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Liver glycolysis/gluconeogenesis and tricarboxylic acid (TCA) cycle intermediates are affected by cancer and chemotherapy. Representative diagram of glycolysis and TCA cycle showing the metabolite concentration (expressed in mM) detected in the liver of vehicle‐treated animals (V), C26 hosts (CC), Folfiri‐treated mice (F), or Folfiri‐treated tumour bearers (CCF). Data are expressed as means ± standard deviation. Statistical significance was evaluated by two‐way analysis of variance, and significant differences (at least P < 0.05) were reported as ^a P vs. V; ^b P vs. CC; ^c P vs. F.