Fig. 3. The chelator–peptide (compound 2) fully protects FRDA fibroblasts against UVA-induced cell death. Human fibroblasts (a) and mouse fibroblasts (b) were treated (or not) overnight with 50 μM compound 2, then irradiated with UVA and the percentage of live cells was determined 24 h post-treatment by flow cytometric Annexin V/PI double-labelling. UVA doses used: 500 kJ m^–2 for human cells, 250 kJ m^–2 for mouse cells. Results from 3–6 independent experiments are expressed as means ± standard deviation (SD) of percentage live cells. * significantly different (p < 0.05) from irradiated control cells. † significantly different (p < 0.05) from corresponding sample irradiated with UVA alone. Representative dot-plots shown for human fibroblasts (c) and for mouse fibroblasts (d).