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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):623–634. doi: 10.1161/ATVBAHA.118.312135

Figure 1. Epigenetic enzymes that regulate macrophage phenotype.

Figure 1.

Epigenetic enzymes that regulate histone methylation and acetylation are shown with their influence on macrophage phenotype. Of note the enzymes written in italics have been shown to have both activating and repressive effects in the literature. BET, Bromodomain and extra-terminal; EZH, Enhancer of zeste homolog 2; HDAC, histone deacetylase; JMJD, Jumonji domain-containing protein; MLL, Mixed-lineage leukemia; PRMT1, Protein arginine N-methyl transferase 1; SET, SET domain containing lysine methyltransferase; SETDB, SET domain bifurcated; SIRT, Sirtulin; SMYD, SET and MYN domain; UTX, Ubiquitously transcribed tetratricopeptide repeat, X chromosome.