Table 1.
Published MRI findings in HAT
| Author and year of publication | MRI findings | Follow-up imaging |
| Spinazzola et al 19899 (WAT) | ↑SI frontal and temporal white matter | None |
| Serrano-Gonzalez et 199610 (WAT) | Bilateral white matter ↑SI extending into basal nuclei and brainstem | Resolution of signal abnormalities |
| Sabbah et al 199711 (EAT) | ↑SI in the internal capsules, cerebellum and splenium of corpus callosum with meningeal thickening | None |
| Bedat-Millet et al 200012 (WAT) | Bilateral white matter and cerebellar ↑SI | None |
| Sahlas et al 2002 and Gill et al 200313, 14 (WAT) | ↑SI in the basal ganglia, internal and external capsules with little contrast enhancement | 1-year follow up: residual ↑SI and ventricular enlargement |
| Braakman et al 200615 (EAT) | Bilateral ↑SI of deep white and grey matter | None |
| Kumar et al 200616 (EAT) | Bilateral ↑SI in subcortical white matter, cerebellum, brainstem and cervical spine | None |
| Checkley et al 20078 (EAT) | ↑SI in internal capsule and corpus callosum with microhaemorrhages (PTRE) | None |
| Kager et al200917 (WAT) | Bilateral ↑SI of deep white matter, basal ganglia and mesencephalon | 4 years follow up: remnant ↑SI and ventricular enlargement |
| Gillmore et al 200918 (Unknown) | Diffuse ↑SI in the deep white matter with less striking changes in the deep grey matter and brainstem | None |
| Liu et al 201019 (WAT) | ↑SI of the subcortical white matter, midbrain and pons | None |
| Wengert et al 201420 (WAT) | ↑SI in hemispheric deep white matter, deep grey matter and brain stem. | 2 years follow up: subtle ventricular enlargement and resolution of ↑SI |
HAT, human African trypanosomiasis; WAT, West African trypanosomiasis; EAT, East African trypanosomiasis; ↑SI, high signal intensity ; PTRE, post-treatment reactive encephalopathy.