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ncRNAs involved in taxane resistance in gastric cancer.
| Drug | NcRNA | Dysregulation | Effect on drug resistance | Target/pathway | Refs. |
|---|---|---|---|---|---|
| Paclitaxel | miR-34c-5p | ↓ | Reversing | MAPT | (141) |
| Docetaxel | miR-361-5p | ↓ | Reversing | Autophagy/PI3K/Akt/mTOR | (142) |
| Cabazitaxel | / | / | / | / | / |
| Abraxane | / | / | / | / | / |
MAPT, microtubule-associated protein tau; PI3K, phosphoinositide 3-kinase; Akt, protein kinase B; mTOR, mammalian target of rapamycin; /, not mentioned; ↑, upregulation; ↓, downregulation.
