Figure 1.

Effects of Solamargine on the morphology and viability of GC cells. (A) Effects of Solamargine on cellular morphology. GC cell lines (AGS, BGC823, SGC7901, HGC27 and MGC803) were treated with Solamargine (10 µM) for 48 h. Magnification, ×10. (B) Solamargine decreased the viability of GC cells. GC cell lines (AGS, BGC823, SGC7901, HGC27, and MGC803) were treated with different concentrations of Solamargine (0, 2.5, 5 and 10 µM). Subsequently, the cell viability was determined with the IncuCyte ZOOM Live-Cell Analysis System every 8 h. ^*P<0.05, ^**P<0.01 vs. control. The IC₅₀ for 6 GC cell lines were calculated by GraphPad Prism statistical software (version 5.0). GC, gastric cancer; IC₅₀, half-maximal inhibitory concentration.