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. 2019 Feb 27;54(5):1676–1690. doi: 10.3892/ijo.2019.4726

Figure 3.

Figure 3

According to reverse transcription-quantitative polymerase chain reaction and western blot analysis, LOXL2 and FAK/Src signaling pathway-associated genes are highly expressed in RCC tissues, and genes associated with the epithelial-to-mesenchymal transition are affected. (A) mRNA expression of LOXL2, FAK, Src, MMP-9, N-cadherin and vimentin was increased in RCC tissues, whereas that of E-cadherin was decreased compared with adjacent normal tissues. (B) Protein expression of LOXL2, FAK, Src, MMP-9, N-cadherin and vimentin were increased in RCC tissues, whereas that of E-cadherin was decreased, in contrast to the adjacent normal tissues; n=80. (C) Quantified protein expression of LOXL2, FAK, P-FAK, Src, P-Src, MMP-9, E-cadherin, vimentin and N-cadherin. Paired t-test was used for analysis; *P<0.05 vs. adjacent normal tissues. LOXL2, lysyl oxidase-like 2; Src, steroid receptor coactivator; FAK, focal adhesion kinase; RCC, renal cell carcinoma; MMP, matrix metalloproteinase; P-, phosphorylated; N-cadherin, neuronal cadherin; E-cadherin, epithelial cadherin.