Skip to main content
. 2019 Feb 27;54(5):1591–1600. doi: 10.3892/ijo.2019.4728

Figure 4.

Figure 4

Analysis of the PI3K/AKT signaling pathway based on the KEGG database. (A) PPI network analysis of 36 target genes involved in the PI3K/AKT signaling pathway in plenti-MRPL33-L-transfected cells and in (B) plenti-MRPL33-S-transfected cells. (C) Map of the PI3K/AKT signaling pathway with the 36 target genes based on the KEGG database. Red and blue represent the upregulation and downregulation of genes, respectively. The size of circle in (A) and (B) indicates significance based on P-value. The square and rounded square in (C) represent genes in plenti-MRPL33-L- and plenti-MRPL33-S-trans-fected cells, respectively. *P<0.05, **P<0.01 and ***P<0.001. PI3K, phosphoinositide 3-kinase; AKT, AKT serine/threonine kinase; KEGG, Kyoto Encyclopedia of Genes and Genomes; PPI, protein-protein interaction; MRPL33, mitochondrial ribosomal protein L33; L, long variant; S, short variant.