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. 2019 Mar 19;54(5):1567–1578. doi: 10.3892/ijo.2019.4756

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Expression of exosomal miR-8485 was gradually elevated. (A) The miRNA from the N-exo, LK-exo and Ca-exo groups was analyzed. Among the miRNAs measured with fold change >2, the expression levels of miR-4433a and miR-8485 were both changed. (B) The expression of miR-8485 in the clinical tissues was assessed by reverse transcription-quantitative polymerase chain reaction. The box represents the interquartile range (25-75th percentile) and the line within this box is the median value. The bottom and top bars of the whisker plot indicate the 10th and 90th percentiles, respectively. (C) DOK cells treated with LK-exo and Ca-exo exhibited elevated expression of miR-8485. (D) SCC15 cells treated with LK-exo and Ca-exo exhibited elevated expression of miR-8485. ^*P<0.05 and ^**P<0.01. miR, microRNA; N-exo, exosomes from mesenchymal stem cells derived from normal oral mucosa; LK-exo, exosomes from mesenchymal stem cells derived from oral premalignant lesion; Ca-exo, exosomes from mesenchymal stem cells derived from oral carcinoma.