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. 2019 Mar 19;54(5):1567–1578. doi: 10.3892/ijo.2019.4756

Figure 6.

Figure 6

Overexpression of miR-8485 promotes the migration and invasion of DOK and SCC15 cells. (A) The miR-8485 mimics and mimics control (NC-mimics) were transfected into DOK cells, and the efficiency was assessed by reverse transcription-quantitative polymerase chain reaction. (B) The miR-8485 mimics and mimics control (NC-mimics) were transfected into SCC15 cells, and the efficiency was assessed by reverse transcription-quantitative polymerase chain reaction. (C) The effect of the miR-8485 mimics on proliferation was analyzed by assessing cell confluence of DOK cells. (D) The effect of the miR-8485 mimics on proliferation was analyzed by assessing cell confluence of SCC15 cells. (E) The relative migration width of the DOK cells following overexpression of miR-8485 was determined with a wound healing assay. Representative images with a magnification of ×10 are depicted. (F) The relative migration width of the SCC15 cells following overexpression of miR-8485 was determined with a wound healing assay. Representative images with a magnification of ×10 are depicted. (G) The Matrigel invasion assay indicated the invasion ability of the DOK cells. Representative images with a magnification of ×20 are depicted. (H) The Matrigel invasion assay indicated the invasion ability of the SCC15 cells. Representative images with a magnification of ×20 are depicted. *P<0.05 and **P<0.01, compared with NC groups. NC, negative control; miR, microRNA.