Table 4. Predictors of PCS and MCS estimated by multivariable linear regression analysis of case-complete participants (n = 14,371).
| Women using OC (n = 1,984) | Women not using OC (n = 4,770) | Men (n = 7,617) | Men and women not using OC (n = 12,387) | |||||
|---|---|---|---|---|---|---|---|---|
| Outcome: PCS | RC | (95% CI) | RC | (95% CI) | RC | (95% CI) | RC | (95% CI) |
| Low-grade inflammation (LGI) | -0.36 | (-0.94; -0.19) | -0.63 | (-1.05; -0.21) | -0.76 | (-1.10; -0.42) | -0.78 | (-1.13; -0.44) |
| BMI (kg/m2) | -0.06 | (-0.13; -0.01) | -0.09 | (-0.13; -0.04) | -0.11 | (-0.14; -0.07) | -0.10 | (-0.12; -0.07) |
| Current smoker (yes/no) | -0.67 | (-1.09; -0.25) | -0.67 | (-0.95; -0.38) | -0.57 | (-0.80; -0.36) | -0.62 | (-0.79; -0.44) |
| Age (10 year increment) | 0.14 | (-0.07; 0.36) | -0.26 | (-0.36; -0.17) | -0.16 | (-0.23; -0.09) | -0.20 | (-0.26; -0.15) |
| Waist (10 cm increment) | -0.39 | (-0.62; -0.17) | -0.25 | (-0.41; -0.09) | -0.30 | (-0.41; -0.19) | -0.29 | (-0.38; -0.19) |
| Physical activity, work (low/high) | -0.11 | (-0.49; 0.27) | -0.43 | (-0.69; -0.17) | -0.51 | (-0.70; -0.33) | -0.48 | (-0.64; -0.33) |
| Physical activity, leisure (low/high) | 0.48 | (0.14; 0.81) | 0.73 | (0.50; 0.96) | 0.70 | (0.52; 0.87) | 0.71 | (0.57; 0.85) |
| Female | -0.18 | (-0.48; 0.12) | ||||||
| Female x LGI | -0.02 | (-0.54; 0.49) | ||||||
| Outcome: MCS | RC | (95% CI) | RC | (95% CI) | RC | (95% CI) | RC | (95% CI) |
| Low-grade inflammation (LGI) | 0.27 | (-0.37; 0.92) | -0.05 | (-0.73; 0.62) | 0.04 | (-0.49; 0.57) | 0.12 | (-0.50; 0.74) |
| BMI (kg/m2) | -0.005 | (-0.13; 0.12) | 0.05 | (-0.02; 0.12) | -0.03 | (-0.08; 0.03) | 0.01 | (-0.04; 0.05) |
| Current smoker (yes/no) | -1.05 | (-1.83; -0.26) | -0.89 | (-1.35; -0.43) | -0.82 | (-1.16; -0.47) | -0.84 | (-1.12; -0.57) |
| Age (10 year increment) | 1.17 | (0.76; 1.58) | 1.24 | (1.09; 1.39) | 1.00 | (0.90; 1.11) | 1.08 | (1.01; 1.17) |
| Waist (10 cm increment) | -0.40 | (-0.82; 0.019) | -0.12 | (-0.37; 0.13) | -0.03 | (-0.21; 0.15) | -0.06 | (-0.21; -0.08) |
| Physical activity, work (low/high) | -0.08 | (-0.79; 0.62) | 0.47 | (-0.05; 0.90) | 0.64 | (0.35; 0.93) | 0.56 | (0.32; 0.80) |
| Physical activity, leisure (low/high) | 0.99 | (0.36; 1.61) | 1.04 | (0.68; 1.42) | 1.16 | (0.88; 1.44) | 1.11 | (0.89; 1.34) |
| Female | 1.01 | (0.79; 1.24) | ||||||
| Female x LGI | -0.12 | (-0.94; 0.69) | ||||||
RC: regression coefficient, OC: combined oral contraception, PCS: physical component score, MCS: mental component score, CRP: C-reactive protein, BMI: body mass index, LGI defined as 3 mg/L < CRP ≤ 10 mg/L, CI: confidence interval.
Note: Analysis performed without missing responses in abdominal obesity variable