Table 6. Mediation analysis of predictors for mental component score with LGI as mediator on case-complete participants with adjustments (n = 14,371).
| Women using OC (n = 1,984) |
Women not using OC (n = 4,770) |
Men (n = 7,617) |
||||
|---|---|---|---|---|---|---|
| Outcome MCS / Mediator LGI | RC | 95% CI | RC | 95% CI | RC | 95% CI |
| BMI (kg/m2) | ||||||
| ACME | 0.001 | -0.001; 0.006 | -0.00003 | -0.0006; 0.0007 | 0.00001 | -0.0002; 0.0002 |
| Direct effect | 0.001 | -0.14; 0.15 | 0.05 | -0.001; 0.10 | -0.03 | -0.07; 0.02 |
| Total effect | 0.003 | -0.14; 0.15 | 0.05 | -0.002; 0.10 | -0.03 | -0.07; 0.02 |
| Proportion of total effect (%) | 0.9 | -24.4; 37.9 | -0.006 | -0.4; 0.2 | -0.04 | -0.6; 0.4 |
| Current smoker (yes/no) | ||||||
| ACME | -0.05 | -0.03; 0.01 | -0.003 | -0.03; 0.02 | 0.001 | -0.02; 0.02 |
| Direct effect | -1.01 | -1.72; -0.28 | -0.87 | -1.34; -0.39 | -0.80 | -1.16; -0.43 |
| Total effect | -1.02 | -1.72; -0.29 | -0.88 | -1.34; -0.40 | -0.80 | -1.16; -0.43 |
| Proportion of total effect (%) | 0.5 | 0.3; 1.6 | 0.3 | 0.2; 0.8 | -0.001 | -0.1; -0.05 |
| Age (10 year increment) | ||||||
| ACME | 0.01 | -0.01; 0.03 | 0.0001 | -0.002; 0.03 | 0.0001 | -0.003; 0.03 |
| Direct effect | 1.18 | 0.81; 1.56 | 1.25 | 1.12; 1.39 | 1.00 | 0.91; 1.10 |
| Total effect | 1.19 | 0.82; 1.57 | 1.25 | 1.12; 1.39 | 1.00 | 0.91; 1.10 |
| Proportion of total effect (%) | 0.6 | 0.5; 0.9 | 0.01 | 0.013; 0.02 | 0.01 | 0.013; 0.02 |
| Waist (10 cm increment) | ||||||
| ACME | 0.0007 | -0.0007; 0.002 | -0.0005 | -0.006; 0.004 | -0.000009 | -0.005; 0.005 |
| Direct effect | -0.35 | -0.67; -0.02 | -0.08 | -0.28; 0.13 | -0.08 | -0.23; 0.08 |
| Total effect | -0.34 | -0.66; -0.01 | -0.08 | -0.28; 0.13 | -0.08 | -0.23; 0.08 |
| Proportion of total effect (%) | -2.0 | -10.2; 0.9 | 0.4 | -7.5; 8.2 | 0.1 | -1.0; 1.0 |
| Physical activity, work (low/high) | ||||||
| ACME | 0.004 | -0.01; 0.03 | -0.001 | -0.01; 0.01 | 0.0001 | -0.01; 0.01 |
| Direct effect | -0.06 | -0.63; 0.54 | 0.49 | 0.10; 0.90 | 0.64 | 0.35; 0.94 |
| Total effect | -0.06 | -0.63; 0.54 | 0.49 | 0.10; 0.90 | 0.64 | 0.35; 0.94 |
| Proportion of total effect (%) | -0.9 | -20.6; 18.3 | -0.2 | -1.1; -0.1 | 0.02 | 0.01; 0.03 |
| Physical activity, leisure (low/high) | ||||||
| ACME | -0.01 | -0.04; 0.01 | 0.002 | -0.01; 0.02 | -0.0001 | -0.01; 0.01 |
| Direct effect | 1.00 | 0.42; 1.61 | 1.06 | 0.67; 1.47 | 1.17 | 0.91; 1.45 |
| Total effect | 0.99 | 0.42; 1.59 | 1.06 | 0.68; 1.47 | 1.17 | 0.91; 1.45 |
| Proportion of total effect (%) | -1.0 | -2.4; -0.6 | 0.2 | 0.1; 0.3 | -0.01 | -0.01; -0.008 |
RC: regression coefficient, OC: combined oral contraception, PCS: physical component score, MCS: mental component score, CRP: C-reactive protein, BMI: body mass index, LGI: low-grade inflammation (defined as 3 mg/L < CRP ≤ 10 mg/L), CI: confidence interval
Note: Analysis performed without missing responses in waist circumference variable