Table 4.
Binding activity (Ki, nm) of penfluridol and its analogs at selected CNS receptors. Data represent mean inhibition (n = 4). NA – not active; ND – not determined.
| KOR | MOR | DOR | H1 | H2 | NET | SERT | DAT | |
|---|---|---|---|---|---|---|---|---|
| PFL | 10,000 | 867 | 1714 | 10,000 | 10,000 | 588 | 10,000 | 1714 |
| 11a | 667 | 902 | 1558 | 814 | 252 | 902 | 903 | 1191 |
| 8a | 2669 | 356 | 1413 | ND | 546 | 77 | 428 | 529 |
| 6 | 1021 | 328 | ND | 718 | 526 | ND | ND | ND |
| 11b | 10,000 | 10,000 | 10,000 | NA | NA | 458 | 10,000 | 10,000 |
| 8b | 1328 | 70 | 1526 | ND | 278 | 518 | 1180 | 121 |
| 8c | 10,000 | 8253 | 10,000 | 7031 | NA | 1438 | 1314 | 622 |
| 13 | 1705 | 536 | NA | 718 | 401 | ND | ND | ND |