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. 2019 Mar 28;14(3):e0214424. doi: 10.1371/journal.pone.0214424

Table 1. Comparison of C6 effect on hormonal profile parameters during the yearly reproductive cycle.

LH
(median and 95% CI)
FSH
(median and 95% CI)
Progesterone
(median and 95% CI)
Breeding season Non-breeding season Onset of the breeding season Breeding season Non-breeding season Onset of the breeding season Breeding season Non-breeding season Onset of the breeding season
Peak onset 1
(0.5–1 hour)
0.5
(0.5–1 hour)
1
(0.5–1.5 hours)
2
(2.0–3.0 hours)
2.25
(1.0–3.0 hours)
2.25
(1.5–4.5 hours)
4 (3–5 days) 3 (2–4 days) 3 (3–4 days)
Time of peak maximum 3.7 (3.1–4.7 hours) 5 (3.5–6.4 hours) 6 (3.7–7.1 hours) 4
(3.0–4.5 hours)
5
(3.5–14.0 hours)
5.75
(4.5–6.0 hours)
_ _ _
Peak duration 10
(7–15 hours)
13.5
(8.5–25.5 hours)
20.5
(10–25 hours)
6
(5.0–24.0 hours)
9.75
(8.5–15.0 hours)
8.5
(1.5–24.0 hours)
_ _ _
AUC 159.1
(98.9–187.3 ng·h·mL-1)
172.7 (103.4–297.7 ng·h·mL-1) 312.1 (55.8–632 ng·h·mL-1) 12.2
(7.7–17.6 ng·h·mL-1)
13.6
(2.5–25.3 ng·h·mL-1)
17.0
(5.0–30.4 ng·h·mL-1)
_ _ _
Maximal amplitude 48.6 (23.4–60.4 ng·mL-1) 25.8 (10.7–57.4 ng·mL-1)a 59.6 (2.0–139.5 ng·mL-1)a 2.9
(1.8–3.9 ng·mL-1)
1.5
(0.5–3.8 ng·mL-1)
2.4
(0.7–3.5 ng·mL-1)
4.6*
(0.25–12.7 ng·mL-1)
5.2*
(4.4–6.0 ng·mL-1)
7.6*
(4.1–11.0 ng·mL-1)

*Amplitude on the last sampling day. Statistical analysis was performed by applying the permutation test.

a indicates a difference between onset of the breeding season and the non-breeding season (P<0.05).