Secondary reproductive: menstrual regularity and ovulation
Study	Menstrual regularity	Ovulation
Brown 2009	No data	No data
Guzick 1994	No data	4/6 people ovulatory versus 1/6 people ovulatory OR 6.59, 95% CI 0.73 to 59.34, P = 0.09
Hoeger 2004	Menstrual cycles per participant (mean ± SD) 24 weeks: 2.88 ± 1.7 versus 2.85 ± 1.6 MD 0.03, 95% CI ‐1.64 to 1.70, P = 0.97 48 weeks: 5.4 ± 3.6 versus 4.3 ± 2.1 MD 1.10, 95% CI ‐2.17 to 4.37, P = 0.51 Number of menstrual events (mean): 48 weeks: 6.2 versus 4.7	Ovulations per participant (mean±SD) 24 weeks: 2.25 ± 1.7 versus 2.23 ± 2.1 MD 0.02, 95% CI ‐1.93 to 1.97, P = 0.98 48 weeks: 6.0 ± 3.6 versus 2.8 ± 2.9 based on n = 4 intervention and n = 6 control patients MD 3.20, 95% CI ‐1.02 to 7.42, P = 0.14 Ovulations (mean): 48 weeks: 3.5 versus 2.7 Ovulations/menstrual cycle 24 weeks: ovulations/menstrual cycle: 18/23 (78.2%) versus 16/20 (80%) 48 weeks: ovulations/menstrual cycle: 25/29 (86.2%) versus 17/28 (60.7%)
Hoeger 2008	Mean 2.3 versus 2.5 cycles/24 weeks No reported significant difference in menstrual cycles for lifestyle versus minimal treatment	60% ovulatory cycles versus 50% ovulatory cycles No comment on significance of comparison for lifestyle versus minimal treatment
Stener‐Victorin 2009‐2013	Change in menstruation frequency (month) after 16 weeks of intervention (mean ± SD) Intervention: 0.14 ± 0.33 Control: ‐0.04 ± 0.007 Change in menstruation frequency (month) at 16 weeks follow‐up (16 weeks after last intervention treatment) Intervention: 0.11 ± 0.36 Control: ‐0.04 ± 0.07 No comment on significance of comparison for lifestyle versus minimal treatment
Vigorito 2007	27/45 (60%) of treatment normal menstrual cycles No data reported for minimal treatment group No comment on significance of comparison for lifestyle versus minimal treatment	No data