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. 2019 Mar 6;149(1):41–53. doi: 10.1111/jnc.14646

Figure 1.

Figure 1

(a) Structures of the muscimol precursor ibotenic acid, GABA and the GABAAR agonists muscimol and THIP. The backbone of GABA is shown in bold to illustrate that muscimol and THIP are conformationally restricted GABA analogs. (b) [3H]Muscimol (6 nM) autoradiography in brain sections comparing wild‐type (WT) with α6 knockout (α6KO) and delta knockout (δKO) mouse lines. This shows that high‐affinity muscimol binding in the forebrain is δ subunit dependent, wheras in the cerebellum it is α6 subunit dependent. Figure for δKO and the corresponding WT mice are reproduced with permission of the Proceedings of the National Academy of Sciences, U.S.A. (Mihalek et al. 1999) and that of α6KO and WT mice with permission of the American Society for Pharmacology and Experimental Therapeutics (Mäkelä et al. 1997).