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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Arthritis Rheumatol. 2019 Mar 5;71(4):632–640. doi: 10.1002/art.40773

Figure 5. Renal histopathology of BDF1 lupus mice after treatment with NPs encapsulated with IL-2/TGF-β and coated with anti-CD4/CD2 Ab.

Figure 5.

Histology of 4-μm kidney sections stained with hematoxylin/eosin (top) and indirect immunofluorescence for IgG (middle). Representative of six mice per group. Magnification: 20x. C. Cumulative glomerular activity score (GAS) and tubulointerstitial activity score (TIAS) in kidneys from mice treated with vehicle, unconjugated of T-cell targeted NPs (n=6 per group) (bottom). Readings were done six weeks after start of treatment. Values are mean ±SD; *P<0.001 vs vehicle group for both GAS and TIAS.

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