HSD17B13-related SNPs are associated with liver disease. Association of rs6834314 genotype with (A) liver histology scores and (B) blood levels of liver enzymes in subjects with NAFLD. (AA, n=485; GA, n=226; GG, n=41). (C) Association of rs6834314 genotype with liver histology scores in subjects with chronic hepatitis C. (AA, n=165; GA, n=125; GG, n=23). (D) Association of rs72613567 genotype with liver histology scores in subjects with NAFLD. (--, n=503; -A, n=220; AA, n=35). (E) Association of rs62305723 genotype with liver histology scores in subjects with NAFLD. (GG, n=615; GA/AA, n=76). Mean±SEM. P-values for histology from multivariate ordinal regression adjusted for age, gender, and BMI. P-values for enzymes from linear regression of log-transformed enzyme activity, adjusted for age, gender, and BMI.