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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Hepatology. 2019 Mar 5;69(4):1504–1519. doi: 10.1002/hep.30350

Figure 6.

Figure 6.

HSD17B13 delta 6 and G-insertion variants localize with lipid droplets, lose RDH activity, and are associated with rs72613567. (A) Schema of HSD17B13 variants A, delta 6, and G-insertion. (B) In HepG2 cells transfected with HSD17B13-delta 6-Flag or HSD17B13-G insertion-Flag the mutant proteins can be detected in lipid droplets stained by LipidTox. (C) Transfection of HEK293 cells with HSD17B13-delta 6 or HSD17B13-G insertion does not lead to increased retinoic acid levels. The delta 6 (D)and G-insertion (E) variants are only detected in subjects who carry the rs72613567 minor A allele.