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All ALIs, regardless of T2R38 genotype, responded with increased NO production upon stimulation with OM-85BV. Cultures homozygous for the functional form of the T2R38 receptor (PAV/PAV) demonstrated a statistically significant greater increase of approximately 40 DAF-FM units compared to AVI/AVI cultures (n=2–3 cultures per condition). A) NO response to OM-85BV over a period of 5 min B) NO release for each condition as the average DAF-FM fluorescence over last 30 seconds.
