Table 1.
A concise table for 13 uPE1 proteins with high confidence predicted functions for MF. For each of the three aspects, MF, BP and CC, the GO term with the highest confidence and the GO term with Cscore >0.5 that can provide specific biological insight are listed, with the Cscore enclosed by parentheses. The four entries discussed as case studies in the following sections are indicated with asterisks. The entries are in descending order according to MF Cscore.
| NeXtProt ID (Gene Name) | Molecular Function (MF) | Biological Process (BP) | Cellular Component (CC) | |
|---|---|---|---|---|
| 1* | NX_Q8TBR7-2 (FAM57A) | GO:0016740 (1.00) transferase activity GO:0050291 (0.99) sphingosine N-acyltransferase activity |
GO:0032502 (0.69) developmental process GO:0007420 (0.54) brain development |
GO:0005887 (1.00) integral component of plasma membrane GO:0005886 (1.00) plasma membrane |
| 2 | NX_Q12767–1 (TMEM94) | GO:0022892 (0.91) substrate-specific transporter activity GO:0046873 (0.57) metal ion transmembrane transporter activity |
GO:0065008 (0.80) regulation of biological quality GO:0030001 (0.56) metal ion transport |
GO:0005654 (1.00) nucleoplasm |
| 3 | NX_Q5BKU9-1 (OXLD1) | GO:0016491 (0.87) oxidoreductase activity GO:0004128 (0.73) cytochrome-b5 reductase activity, acting on NAD(P)H |
GO:0015701 (0.90) bicarbonate transport GO:0008652 (0.53) cellular amino acid biosynthetic process |
GO:0005739 (0.90) Mitochondrion GO:0005737 (0.66) cytoplasm |
| 4* | NX_A6NGC4-1 (TLCD2) | GO:0016740 (0.86) transferase activity GO:0050291 (0.76) sphingosine N-acyltransferase activity |
GO:0006643 (0.76) membrane lipid metabolic process GO:0006672 (0.73) ceramide metabolic process |
GO:0016021 (1.00) integral component of membrane GO:0005783 (0.75) endoplasmic reticulum |
| 5* | NX_O43934–1 (MFSD11) | GO:0005215 (0.85) transporter activity GO:0005351 (0.66) sugar:proton symporter activity |
GO:0006810 (0.82) transport GO:0008643 (0.68) carbohydrate transport |
GO:0016021 (1.00) integral component of membrane GO:0005887 (0.77) integral component of plasma membrane |
| 6 | NX_Q9P298–1 (HIGD1B) | GO:0016740 (0.79) transferase activity GO:0061630 (0.71) ubiquitin protein ligase activity |
GO:0043234 (0.88) protein complex GO:0005634 (0.71) nucleus |
|
| 7 | NX_Q2TAL5-1 (SMTNL2) | GO:0008092 (0.77) cytoskeletal protein binding | GO:0016043 (0.70) cellular component organization GO:0048856 (0.59) anatomical structure development |
GO:0005737 (0.66) Cytoplasm GO:0044430 (0.50) cytoskeletal part |
| 8 | NX_Q9BQS6-1 (HSPB9) | GO:0042802 (0.76) identical protein binding GO:0051082 (0.52) unfolded protein binding |
GO:0050896 (0.82) response to stimulus GO:0042981 (0.51) regulation of apoptotic process |
GO:0005634 (0.97) Nucleus GO:0005737 (0.96) cytoplasm |
| 9 | NX_Q96LD4–1 (TRIM47) | GO:0004842 (0.76) ubiquitin-protein transferase activity | GO:0031323 (0.54) regulation of cellular metabolic process GO:0019538 (0.54) protein metabolic process |
GO:0005737 (0.57) cytoplasm |
| 10 | NX_Q8N7B9-1 (EFCAB3) | GO:0043169 (0.74) cation binding | GO:0019538 (0.58) protein metabolic process | GO:0016020 (0.82) Membrane GO:0005737 (0.68) cytoplasm |
| 11* | NX_Q6AI12–1 (ANKRD40) | GO:0008092 (0.62) cytoskeletal protein binding GO:0030507 (0.57) spectrin binding |
GO:0060255 (0.62) regulation of macromolecule metabolic process GO:0016043 (0.60) cellular component organization |
GO:0005737 (0.77) Cytoplasm GO:0043234 (0.51) protein complex |
| 12 | NX_Q6UX52-1 (C17orf99) | GO:0004872 (0.63) receptor Activity GO:0019199 (0.50) transmembrane receptor protein kinase activity |
GO:0032502 (0.68) developmental process GO:0030030 (0.54) cell projection organization |
GO:0031224 (1.00) intrinsic component of membrane GO:0005887 (0.63) integral component of plasma membrane |
| 13 | NX_Q3MHD2-1 (LSM12) | GO:0003723 (0.59) RNA binding | GO:0090304 (0.79) nucleic acid metabolic process GO:0016070 (0.73) RNA metabolic process |
GO:0005576 (0.55) extracellular region |