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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: J Neurochem. 2019 Mar 15;149(1):98–110. doi: 10.1111/jnc.14668

Figure 4. Tat upregulates GSK3β activity in immature OLs in vitro.

Figure 4.

(A) Tat induced a dose-dependent upregulation of GSK3β activity (decreased ratio of p-GSK3β-S9/t-GSK3β) in immature OLs. (B) GSK3β activity in mature OLs was not affected by Tat. (C) The upregulated GSK3β activity induced by 100 nM Tat in immature OLs persists over 96 h. (D) Total GSK3β levels in immature OLs were not affected by 100 nM Tat treatment within 96 h. (* p < 0.05 vs. controls lacking Tat; $ p < 0.05 vs. 10 nM Tat). Experiments in A–D represent results from N=4 independent cultures prepared from mice of different litters.