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Lack of interaction between the hepatic CB1R and mTORC1/p70S6K signaling systems.
(A) Effects of JD5037 treatment (3 mg/kg/day for 2 weeks) of HFD-fed wild-type and Sirt1-LKO mice on hepatic Rictor protein, ser256 phosphorylation of the Rictor target FOXO1, and thr389 phosphorylation of the mTORC1 target p70S6K; (B) Lack of effects of CB1R agonists or inverse agonists on insulin induced phosphorylation of mTORC1 and its downstream targets in HepG2 cells.
