Fig. 2.

Effects of pterostilbene on metabolite formation are shown as indexes of CYP and UGT activity in HLM (CYP2C8, CYP3A4, UGT1A1, UGT1A6 and UGT1A9) and in HIM (UGT1A8/10). Each enzyme-selective substrate, CYP2C8 (amodiaquine), CYP3A4 (midazolam), UGT1A1 (estradiol), UGT1A6 (serotonin) and UGT1A8/9/10 (mycophenolic acid) was incubated with HLM or HIM and three concentrations of pterostilbene. The three concentrations of pterostilbene were 1 µM (dotted bars), 10 µM (striped bars) and 100 µM (checkered bars). Error bars represent SE of the mean of duplicate incubations.