Comparison 2. SDAC + hospital intervention vs hospital intervention.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Incidence of mortality	2	3425	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.04 [0.79, 1.37]
2 Incidence of adverse events	3		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 Incidence of vomiting	2	1806	Risk Ratio (M‐H, Random, 95% CI)	1.44 [0.88, 2.37]
2.2 Incidence of absent bowel sounds	1	3098	Risk Ratio (M‐H, Random, 95% CI)	0.41 [0.17, 1.00]
3 Incidence of need for intubation	4	3562	Risk Ratio (M‐H, Random, 95% CI)	1.37 [0.76, 2.47]
3.1 Gastric lavage prior to SDAC	2	3175	Risk Ratio (M‐H, Random, 95% CI)	0.95 [0.70, 1.27]
3.2 No gastric lavage prior to SDAC	2	387	Risk Ratio (M‐H, Random, 95% CI)	2.61 [1.38, 4.93]
4 Incidence of convulsions	2		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
5 Duration of intubation (h)			Other data	No numeric data
6 AUC ((µg/L) × h)			Other data	No numeric data
7 Cmax (µg/L)			Other data	No numeric data
8 Tmax (h)			Other data	No numeric data
9 Incidence of hospitalization	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
10 Incidence of ICU admission	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected