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. 2019 Mar 22;6:14. doi: 10.3389/fmolb.2019.00014

Figure 1.

Figure 1

Overview of proteasome ABPs. (A) Molecular structures of two proteasome ABPs. (B) The principle of how probes target the active proteasome: proteasome ABPs enter through the 20S proteasome gate, and covalently target the catalytic sites. (C) Typical examples of the detection methods of proteasome ABPs. Left, overlay of the ABP signal in proteasome inhibitor treated (red), untreated (white), and proteasome activator treated (green) MelJuSo cells; Right, In-gel fluorescence scan showing representative proteasome activity profiles of proteasome inhibitor treated, untreated, and proteasome activator treated MelJuSo cells; Below, confocal microscopy images of the ABP signal in proteasome inhibitor treated, untreated and proteasome activator treated MelJuSo cells. (D) Applications of proteasome ABPs.