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. 2019 Mar 22;10:506. doi: 10.3389/fimmu.2019.00506

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Copyright © 2019 Apostolou, Moustardas, Iwawaki, Tzioufas and Spyrou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Autoantibodies in the ERdj5^−/− animal sera. (A) Serum concentrations of anti-nuclear antibodies (ANAs) in female (top panel) and male (bottom panel) ERdj5^−/− mice and wildtype controls at 1.5, 7, and 12 months of age. (B) Detection of specific autoantibodies in the serum of female (top panels) and male (bottom panels) ERdj5^−/− mice and wildtype controls at 1.5, 7, and 12 months of age. Left panels: detection of anti-SSA/Ro52 autoantibodies; Middle panels: detection of anti-SSA/Ro60 autoantibodies; Right panels: detection of anti-SSB/La autoantibodies. Data are represented as individual points for each subject, overlaid by a horizontal mean group value ± SEM. Statistically significant differences are indicated as ^* for p < 0.05, ^** for p < 0.01, ^*** for p < 0.001 and ^**** for p < 0.0001.