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. 2019 Mar 22;10:565. doi: 10.3389/fimmu.2019.00565

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Copyright © 2019 Souza, Souza, Amaral, Lemes, Santucci, Milanski, Torsoni and Torsoni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Survival rate following LPS challenge and CLP surgery of SC-fed and HFD-fed mice. Mice were fed SC or a HFD for 3 days. Subsequently, sepsis was induced by two different methods. (A) A lethal dose of LPS (30 mg/kg) was administered via intraperitoneal injection in mice the received icv injection of PNU (10 pmoles/mouse) (SC-LPS, n = 7 opened circles, HFD-LPS, n = 5 closed circles, SC-lps+pnu, n = 5 opened squares, and HFD-lps+pnu, n = 5 closed squares); or (B) Cecal ligation and puncture surgery was performed (SC-CLP, n = 5 opened squares and HFD-CLP, n = 5 closed squares). The survival rate was recorded every 2 h. The results represent the mean ± S.E.M. (A) ^***p < 0.0001 HFD-lps vs SC-lps, (B) ^*p < 0.05 HFD-CLP vs SC-CLP (log-rank test).