Table 4.
Disease effects in adolescents.
| Brain region | Lat | X (mm) | Y (mm) | Z (mm) | Vol (cm) | Z-stat | |
|---|---|---|---|---|---|---|---|
| Auditory | |||||||
| Migraine > Control | Cortical | ||||||
| Frontal | |||||||
| Sup. Orbital | R | 18 | 34 | 32 | 1.24 | 2.92 | |
| Parietal | |||||||
| Supramarginal | R | 58 | -14 | 28 | 1.8 | 4.22 | |
| Occipital | |||||||
| Inferior | L | -34 | -86 | -4 | 1.03 | 3.12 | |
| Temporal | |||||||
| Superior | R | 62 | -6 | 4 | 1 | 2.70 | |
| L | -62 | -34 | 20 | 2.55 | 2.87 | ||
| Middle | L | -50 | -34 | 4 | 1.61 | 3.59 | |
| Cingulum | |||||||
| Middle | L | -2 | -6 | 48 | 2.79 | 3.94 | |
| CEN –A (10) | |||||||
| Migraine > Control | Cortical | ||||||
| Frontal | |||||||
| Sup. Medial | L | -2 | 46 | 28 | 10.18 | 4.69 | |
| Cingulum | |||||||
| Middle | L | 2 | 18 | 36 | 1.97 | 3.78 | |
| L | -6 | -38 | 36 | 1.39 | 3.64 | ||
| Insula | |||||||
| Anterior | L | -42 | 6 | -12 | 8 | 3.69 | |
| CEN –C (53) | |||||||
| Migraine > Control | Cortical | ||||||
| Parietal | |||||||
| Supramarginal | R | 54 | -34 | 48 | 1.8 | 3.86 | |
| Superior | R | 18 | -46 | 68 | 1.08 | 3.31 | |
| L | -18 | -74 | 52 | 1.42 | 3.75 | ||
| Occipital | |||||||
| Superior | L | -22 | -74 | 40 | 1.25 | 3.77 | |
| Temporal | |||||||
| Lingual | L | -10 | -58 | -8 | 1.46 | 4.18 | |
| R | 2 | -70 | 0 | 1.49 | 4.04 | ||
| Cingulum | |||||||
| Anterior | L | 2 | 26 | 28 | 2.06 | 4.33 | |
| CEN –B (16) | |||||||
| Migraine < Control | Cortical | ||||||
| Parietal | |||||||
| Precuneus | R | 14 | -42 | 48 | 1.13 | 4.39 | |
| DMN – A (03) | |||||||
| Migraine < Control | Cortical | ||||||
| Temporal | |||||||
| Superior | R | 58 | -6 | -12 | 1.03 | 4.59 | |
| FPN Right | |||||||
| Migraine > Control | Cortical | ||||||
| Frontal | |||||||
| Inferior triangular | L | -54 | 22 | 24 | 1.67 | 3.27 | |
| Temporal | |||||||
| Superior | L | -46 | -14 | -12 | 3.41 | 4.17 | |
| Migraine < Control | Cortical | ||||||
| Frontal | |||||||
| Middle | L | -46 | 42 | 16 | 4.58 | 3.89 | |
| SMA | L | -10 | 2 | 72 | 1.17 | 3.99 | |
| Salience | |||||||
| Migraine > Control | Cortical | ||||||
| Frontal | |||||||
| Inf. Orbital | R | 46 | 30 | -8 | 4.18 | 3.34 | |
| Inf. Triangular | R | 54 | 26 | 16 | 1.65 | 3.36 | |
| Inf. Operculum | L | -54 | 14 | 0 | 1.26 | 3.12 | |
| R | 58 | 10 | 4 | 5.09 | 3.76 | ||
| Parietal | |||||||
| Supramarginal | R | 58 | -38 | 36 | 1.02 | 2.53 | |
| Superior | L | -14 | -74 | 48 | 1.52 | 3.36 | |
| Occipital | |||||||
| Middle | R | 46 | -66 | 24 | 1.04 | 3.13 | |
| Temporal | |||||||
| Lingual | L | -18 | -90 | -12 | 1.15 | 2.99 | |
| Insula | |||||||
| Anterior | L | -30 | 30 | 4 | 1.92 | 3.33 | |
| R | 34 | 22 | 4 | 2.09 | 2.91 | ||
| Sub-cortical | |||||||
| Putamen | R | 30 | 6 | 4 | 2.1 | 2.67 | |
| Migraine < Control | Cortical | ||||||
| Parietal | |||||||
| Angular | R | 42 | -62 | 48 | 1.46 | 3.88 | |
| Cingulum | |||||||
| Middle | L | -2 | 22 | 32 | 2.62 | 3.41 | |
| Brainstem/cerebellum | |||||||
| Cerebellum 8 | R | 22 | -54 | -48 | 1.29 | 3.42 | |
| SMN –B (21) | Cortical | ||||||
| Migraine > Control | Frontal | ||||||
| Mid. Orbital | L | -2 | 54 | -4 | 1.47 | 3.19 | |
| R | 26 | -2 | 48 | 9.7 | 4.05 | ||
| R | 42 | -2 | 56 | 1.44 | 2.79 | ||
| Inf. Orbital | L | -22 | 10 | -24 | 1.05 | 3.64 | |
| Sup. Orbital | R | 30 | 2 | 60 | 2.06 | 3.27 | |
| R | 30 | -14 | 60 | 1.73 | 3.78 | ||
| Inf. Triangular | L | -46 | 18 | 8 | 1.09 | 2.72 | |
| Inf. Operculum | R | 58 | 14 | 16 | 1.13 | 3.43 | |
| R | 34 | 6 | 28 | 2.28 | 3.07 | ||
| SMA | R | 2 | 10 | 52 | 3.7 | 3.12 | |
| R | 6 | 18 | 56 | 2.7 | 3.08 | ||
| L | -10 | 2 | 60 | 3.07 | 2.99 | ||
| R | 6 | -14 | 64 | 3.8 | 2.67 | ||
| R | 14 | -18 | 68 | 1.26 | 2.55 | ||
| Precentral | R | 46 | 6 | 40 | 1.94 | 2.7 | |
| L | -30 | -18 | 56 | 8.14 | 3.28 | ||
| R | 46 | -10 | 36 | 1.42 | 3.3 | ||
| Middle | L | -30 | 18 | 44 | 2.45 | 2.76 | |
| Superior | L | -22 | -2 | 56 | 1.1 | 2.53 | |
| R | 10 | 42 | 40 | 7.58 | 2.83 | ||
| Rectus | R | 6 | 34 | -16 | 1.14 | 2.88 | |
| Sup. Medial | L | -2 | 22 | 40 | 14.74 | 3.35 | |
| Parietal | |||||||
| Postcentral | R | 34 | -34 | 60 | 1.28 | 2.6 | |
| L | -30 | -38 | 64 | 3.85 | 2.81 | ||
| R | 30 | -46 | 56 | 2.45 | 3.74 | ||
| Precuneus | L | -2 | -58 | 16 | 1.85 | 2.64 | |
| Occipital | |||||||
| Rolandic Operculum | R | 54 | 2 | 16 | 2.28 | 3.28 | |
| Inferior | R | 50 | -70 | -16 | 1.33 | 2.84 | |
| Temporal | |||||||
| Superior | L | -62 | -6 | 0 | 1.99 | 3.18 | |
| Heschl | R | 54 | -14 | 8 | 1.93 | 3.16 | |
| Fusiform | L | -42 | -54 | -12 | 1.04 | 3.13 | |
| L | -34 | -82 | -16 | 1.74 | 2.69 | ||
| Cingulum | |||||||
| Anterior | R | 2 | 34 | -8 | 1.84 | 2.83 | |
| R | 6 | 10 | 28 | 1.56 | 2.88 | ||
| Middle | R | 10 | 14 | 40 | 1.38 | 2.59 | |
| R | 2 | 2 | 44 | 1.36 | 2.5 | ||
| L | -6 | -10 | 36 | 2.66 | 3.17 | ||
| R | 10 | -26 | 36 | 1.39 | 3.19 | ||
| Sub-cortical | |||||||
| Putamen | R | 26 | 18 | 4 | 1.89 | 3.39 | |
| L | -26 | -2 | 8 | 2.19 | 3.31 | ||
The table indicates brain areas of significant increased or decreased connectivity with the listed networks for adolescents with migraine vs. healthy controls. Coordinates and max statistical value (z-stat) are given for peak activity as well as volume (Vol) of each cluster of activity. “Lat” indicates the brain laterality (i.e., R, right side, L, left side).