Table 6.
Interaction between groups – Adolescents (Mg > Hc) > Young adults (Mg > Hc).
| Brain region | Lat | X (mm) | Y (mm) | Z (mm) | Vol (cm) | Z-stat | |
|---|---|---|---|---|---|---|---|
| Cerebellum | |||||||
| Cortical | |||||||
| Parietal | |||||||
| Supramarginal | R | 34 | -38 | 40 | 2.64 | 4.43 | |
| Sub-cortical | |||||||
| Putamen | R | 34 | -2 | 4 | 1.26 | 3.78 | |
| DMN – A (03) | Cortical | ||||||
| Frontal | |||||||
| Medial superior | L | -6 | 42 | 48 | 1.11 | 2.55 | |
| Olfactory | L | -2 | 18 | -16 | 1.7 | 3.54 | |
| Precentral | L | -38 | -2 | 28 | 1.55 | 3.12 | |
| L | -30 | -10 | 64 | 1.31 | 3.06 | ||
| Parietal | |||||||
| Supramarginal | R | 58 | -14 | 24 | 1.71 | 3.3 | |
| Postcentral | R | 26 | -38 | 48 | 1.49 | 3.34 | |
| Precuneus | R | 2 | -46 | 52 | 2.30 | 2.97 | |
| L | -6 | -46 | 8 | 6.86 | 4.14 | ||
| R | 6 | -58 | 32 | 9.77 | 3.07 | ||
| R | 18 | -70 | 40 | 2.29 | 3.95 | ||
| R | 14 | -74 | 44 | 3.08 | 4.06 | ||
| L | -6 | -82 | 44 | 3.33 | 4.05 | ||
| Superior | R | 14 | -50 | 64 | 1.39 | 3.01 | |
| Inferior | R | 46 | -50 | 56 | 1.66 | 2.71 | |
| R | 38 | -54 | 44 | 1.42 | 2.51 | ||
| Occipital | |||||||
| Calcarine | R | 14 | -86 | 4 | 2.55 | 3.44 | |
| Temporal | |||||||
| Middle | L | -50 | -30 | 0 | 2.47 | 3.93 | |
| L | -46 | -58 | 8 | 1.36 | 2.92 | ||
| Lingual | R | 22 | -82 | -8 | 1.26 | 3.07 | |
| Cingulum | |||||||
| Middle | L | -6 | -42 | 36 | 1.43 | 2.41 | |
| Insula | |||||||
| Anterior | L | -34 | 10 | 4 | 1.26 | 3.01 | |
| Posterior | L | -34 | -10 | 16 | 2.17 | 3.35 | |
| L | -42 | -10 | 4 | 1.18 | 2.82 | ||
| Cerebellum | |||||||
| Cerebellum 6 | L | -22 | -58 | -28 | 1.8 | 3.64 | |
| Cerebellum crus 2 | L | -30 | -78 | -40 | 3.33 | 3.59 | |
| DMN – C (35) | |||||||
| Cortical | |||||||
| Frontal | |||||||
| Inferior Operculum | R | 50 | 18 | 0 | 1.55 | 4.09 | |
| Parietal | |||||||
| Postcentral | R | 46 | -26 | 60 | 1.07 | 3.26 | |
| Temporal | |||||||
| Superior | R | 58 | -46 | 20 | 1.44 | 3.34 | |
| Lateral VN – B (62) | |||||||
| Cortical | |||||||
| Parietal | |||||||
| Angular | R | 34 | -66 | 44 | 2.02 | 3.95 | |
| R | 38 | -66 | 48 | 1.27 | 3.82 | ||
| Occipital | |||||||
| Superior | L | -22 | -78 | 40 | 1.44 | 2.84 | |
| Inferior | L | -34 | -82 | -12 | 1.69 | 3.35 | |
| Temporal | |||||||
| Middle | R | 54 | -54 | 4 | 2.93 | 3.53 | |
| Inferior | R | 50 | -54 | -12 | 1.33 | 2.85 | |
| Lingual | L | -26 | -54 | -8 | 1.37 | 3.70 | |
| L | -14 | -82 | -4 | 1.28 | 3.20 | ||
| Cingulum | |||||||
| Posterior | L | -10 | -50 | 32 | 1.08 | 2.96 | |
| Sub-cortical | |||||||
| Hippocampus | R | 26 | -14 | -20 | 1 | 3.42 | |
| Cerebellum | |||||||
| Cerebellum_4_5 | R | 22 | -50 | -20 | 1.06 | 3.67 | |
| Medial VN – A (00) | |||||||
| Cortical | |||||||
| Frontal | |||||||
| SMA | L | -2 | -6 | 72 | 1.76 | 3.61 | |
| Parietal | |||||||
| Postcentral | L | -46 | -14 | 44 | 1.78 | 4.02 | |
| R | 38 | -30 | 64 | 1.3 | 3.67 | ||
| Occipital | |||||||
| Cuneus | L | -14 | -82 | 36 | 1.98 | 3.04 | |
| Temporal | |||||||
| Lingual | R | 26 | -46 | -4 | 1.44 | 3.13 | |
| R | 18 | -62 | -8 | 1.37 | 3.06 | ||
| Cerebellum | |||||||
| Cerebellum_4_5 | R | 18 | -46 | -16 | 1.35 | 3.39 | |
The table indicates brain areas of significant increased connectivity with the listed networks for adolescents with migraine vs. young adults with migraine and healthy controls. Coordinates and max statistical value (z-stat) are given for peak activity as well as volume (Vol) of each cluster of activity. “Lat” indicates the brain laterality (i.e., R, right side, L, left side).