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. 2019 Mar 28;9:5303. doi: 10.1038/s41598-019-41740-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The impact of PSC secretome on PDAC cells. Serum-starved PT45P1 cells were treated with secretome from non-activated or activated PSC; the abundance of key molecules of cell apoptosis and viability were measured in the PT45P1 cellular proteome by using Western blots (A). Variations in apoptosis were studied by two different assays (B) measuring the mitochondrial membrane potential (top) or the caspase-3/7 activity (bottom). In (C), results from Western blots are shown that look at proteins relevant for differentiation.