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. 2019 Mar 28;9:5303. doi: 10.1038/s41598-019-41740-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of the regulative function of eIF4E. Using the IPA analysis software, effects are shown of proteins of the secretome of activated PSCs on eIF4E (upstream factors) as well as the effects of eIF4E on intracellular proteins of the tumour cells. Red indicates an increase, green a decrease in abundance compared to control conditions. Orange stands for activation, blue for inhibition.