Table 2.
Prediction of cellular functions that triggered in PT45P1 tumour cells by the secretome of activated PSCs compared to non-activated PSCs. Proteins that varied are listed.
| Biological Functions | p-Value | Molecules | Molecule Number |
|---|---|---|---|
| Carcinoma | 1.44E-25 | ADAM9, AKT3, ALB, APC, APEX1, AREG/AREGB, AURKB, BAX, BRCA1, BUB1, CCL5, CCNA2, CCNB1, CDH13, CDK4, CDKN1A, CDKN1C, CDKN2A, CDKN2B, CKB, CLDN16, COL1A1, CTSD, CXCL10, CYP2C8, DKK1, EDNRA, EDNRB, EEF1A1, ENO2, EP300, ETS2, EWSR1, FAS, FGF2, FN1, FOLR1, FUBP1, GAPDH, GAS1, GJB1, GNAS, GRP, GSTP1, HMMR, HSPA8, IFI27, IFITM2, IFNA1/IFNA13, IFNG, IFNGR1, IGF1, IGF2, IL10, IL15, IL1B, IL4, IL6, IL8, JUN, KDM5A, KDR, KLF8, LGALS4, LIFR, LMNA, MAGED2, MAPK10, MCM5, MGMT, MIF, MLH1, MMP11, MMP13, MOXD1, MUC2, MXI1, MYBL2, NCL, NOS2, OVGP1, PCNA, PGF, PRDX2, PRKCG, PSMF1, PTK2, RARB, RASSF1, RB1, RPL7, RPS19, RUNX3, S100A4, S100A6, S100A8, S100A9, SDC1, SELE, SERPINE1, SERPINE2, SFRP2, SLC29A1, SLC7A5, SOCS1, SOD1, SPP1, TF, TFPI2, TGFBI, TGFBR2, TIMP1, TIMP2, TNF, TNFSF13, TRAPPC11, TSPAN8, TUBA1A, TUBB, VDR, VEGFA, VEGFC, ZC3H13 | 123 |
| Binding of DNA | 1.35E-23 | AIFM1, ALB, BAX, CCL11, CCL5, CDKN1A, FAS, FCER1A, FGF2, FN1, FPR1, GNAS, IFNG, IGF1, IL10, IL13, IL1B, IL2, IL32, IL4, IL6, IL8, NOS2, NR4A1, PRDX2, RB1, S100A6, SELE, SOD1, TF, TNF, VDR | 51 |
| Apoptosis of pancreatic cancer cell lines | 3.79E-13 | BAX, CASP9, FAS, FGF2, IFNG, JUN, NR4A1, TNF | 14 |
| Induction of lipid | 1.88E-11 | ALB, APEX1, BRCA1, CALR, CDKN1A, CDKN2A, EP300, ETS2, FAS, FGF2, FN1, GNAS, GRP, GSTP1, IFNA1/IFNA13, IFNG, IGF1, IL10, IL13, IL15, IL1A, IL1B, IL2, IL4, IL6, IL8, IRF7, JUN, KDR, LMNA, MAPK3, MGMT, MIF, NFKB1, NFKB2, NR4A1, PCNA, POU2F1, POU5F1, RARB, RASSF1, RB1, SOCS1, SOD1, TF, TNF, TNFAIP3, VDR, VEGFA, YBX1, ZBTB17 | 9 |
| Proliferation of cervical cancer cell lines | 2.70E-11 | C1QC, CDKN1A, CSF2RB, IFNA1/IFNA13, IFNG, IL10, IL13, IL15, IL1A, IL4, IL6, IRF7, SOCS1, TNF | 19 |
| Metabolism of reactive oxygen species | 1.02E-10 | CCL5, FN1, IFNG, IL10, IL2, IL4, IL6, SELE, TIMP2, TNF, VEGFA | 32 |
| Differentiation of cells | 7.70E-09 | FGF2, IL1A, IL1B, TIMP1, TNF | 14 |
| Synthesis of nitrite | 1.31E-08 | FGF2, GRP, IL10, IL15, IL1A, IL1B, IL6, MIF, TNF | 8 |
| Apoptosis of myofibroblasts | 1.77E-08 | BAX, CDKN2A, FAS, BCL2L2, IFNG, IGF1, IL1B, IL32, IL6, IL8, RPS19, S100A4, SOCS1, TNF | 5 |
| Migration of monocytes | 2.04E-08 | ACTB, APEX1, ARID4A, AURKB, CDKN1A, CDKN2A, DKK3, EP300, EWSR1, FOLR1, IFNG, IGF1, IGF2, NCL, RB1, SOCS1, SPP1, TNF, TUBB | 11 |
| Apoptosis of carcinoma cells | 3.84E-08 | ALB, FGF2, IFNG, IGF1, IL4, IL6, IL10, TNF | 8 |
| Cell death of pancreatic cancer cell lines | 3.84E-08 | IFNG, IL13, IL1A, IL1B, IL6, MTA1, NOS2, TNF | 8 |