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. 2019 Mar 28;9:124. doi: 10.1038/s41398-019-0457-y

Fig. 1. Prenatal exposure to poly I:C leads to developmental delays in males and females and altered spontaneous activity and motor coordination in males.

Fig. 1

a Delay in eye opening was measured as the mean number of open eyes (0, 1, or 2) per group from P12 to P16 in males (left) and females (right). b Increased latency to right at P11 and P13 in poly I:C males. c Immobility time when transferred to the SHIRPA arena is increased only in poly I:C males. d Locomotor activity after the transfer to the SHIRPA arena. Only poly I:C males showed a decrease in this parameter. e Time to climb on the grid was found increased in poly I:C mice compared to saline in males only. f Significant increase in time spent climbing the wire was found only in poly I:C males. g No significant change in the time spent grooming was found in poly I:C mice compared to saline. h Poly I:C prenatal exposure significantly decreased the number of vertical rears in the cylinder in poly I:C males only. Poly I:C males n = 11; saline males n = 27; poly I:C females n = 10; saline females n = 30. Data expressed as mean ± SEM; two-way ANOVA followed by Fisher’s LSD post-hoc (d, e, and g), and Kruskal-Wallis test followed by Dunn’s multiple comparisons test (a, b, c, f, and h) (*p < 0.05; **p < 0.01; ****p < 0.0001)