Table 3.
Odds of having neuropsychiatric symptoms by cognitive/amyloid status groups
| Dependent variable | N | Independent variable | N | OR (95% CI) | p |
|---|---|---|---|---|---|
| Depression | 97 | CU/A− | 978 | 1.00 (reference) | |
| 51 | CU/A+ | 441 | 1.13 (0.76, 1.67) | 0.55 | |
| 10 | MCI/A− | 76 | 1.33 (0.65, 2.72) | 0.43 | |
| 31 | MCI/A+ | 105 | 3.48 (2.05, 5.90) | < 0.001 | |
| Anxiety | 42 | CU/A− | 978 | 1.00 (reference) | |
| 27 | CU/A+ | 441 | 1.45 (0.84, 2.50) | 0.18 | |
| 9 | MCI/A− | 76 | 2.82 (1.27, 6.25) | 0.011 | |
| 21 | MCI/A+ | 105 | 5.29 (2.73, 10.23) | < 0.001 | |
| Apathy | 31 | CU/A− | 978 | 1.00 (reference) | |
| 26 | CU/A+ | 441 | 1.62 (0.90, 2.91) | 0.11 | |
| 7 | MCI/A− | 76 | 2.51 (1.03, 6.09) | 0.042 | |
| 24 | MCI/A+ | 105 | 7.06 (3.59, 13.88) | < 0.001 | |
| Irritability | 68 | CU/A− | 978 | 1.00 (reference) | |
| 39 | CU/A+ | 441 | 1.32 (0.84, 2.08) | 0.23 | |
| 16 | MCI/A− | 76 | 3.39 (1.80, 6.38) | < 0.001 | |
| 25 | MCI/A+ | 105 | 4.21 (2.34, 7.58) | < 0.001 | |
| Nighttime behavior | 39 | CU/A− | 879 | 1.00 (reference) | |
| 31 | CU/A+ | 400 | 1.31 (0.77, 2.23) | 0.32 | |
| 5 | MCI/A− | 69 | 1.13 (0.42, 3.06) | 0.81 | |
| 17 | MCI/A+ | 87 | 3.06 (1.52, 6.17) | 0.002 | |
| Any NPS | 192 | CU/A− | 978 | 1.00 (reference) | |
| 110 | CU/A+ | 441 | 1.18 (0.88, 1.58) | 0.27 | |
| 26 | MCI/A− | 76 | 1.77 (1.06, 2.97) | 0.029 | |
| 63 | MCI/A+ | 105 | 4.84 (3.06, 7.65) | < 0.001 | |
| Any non-psychotic NPS | 192 | CU/A− | 978 | 1.00 (reference) | |
| 110 | CU/A+ | 441 | 1.18 (0.88, 1.58) | 0.27 | |
| 26 | MCI/A− | 76 | 1.77 (1.06, 2.97) | 0.029 | |
| 63 | MCI/A+ | 105 | 4.84 (3.06, 7.65) | < 0.001 | |
| BDI-II ≥ 13 | 53 | CU/A− | 977 | 1.00 (reference) | |
| 28 | CU/A+ | 438 | 1.29 (0.77, 2.17) | 0.33 | |
| 8 | MCI/A− | 76 | 1.70 (0.75, 3.87) | 0.20 | |
| 17 | MCI/A+ | 105 | 3.42 (1.75, 6.71) | < 0.001 | |
| BAI ≥ 8 | 83 | CU/A− | 977 | 1.00 (reference) | |
| 45 | CU/A+ | 440 | 1.22 (0.80, 1.86) | 0.35 | |
| 15 | MCI/A− | 76 | 2.88 (1.52, 5.44) | 0.001 | |
| 23 | MCI/A+ | 105 | 2.97 (1.66, 5.30) | < 0.001 | |
| BAI ≥ 10 | 50 | CU/A− | 977 | 1.00 (reference) | |
| 30 | CU/A+ | 440 | 1.45 (0.86, 2.43) | 0.16 | |
| 8 | MCI/A− | 76 | 2.31 (1.02, 5.26) | 0.045 | |
| 14 | MCI/A+ | 105 | 3.01 (1.47, 6.15) | 0.003 |
Significant p values appear bold. Analyses adjusted for age, sex, education, and APOE ε4 genotype status
CU cognitively unimpaired, MCI mild cognitive impairment, A− normal PiB-PET, A+ abnormal PiB-PET, OR odds ratio, CI confidence interval, p value comparing to reference group, BDI-II Beck Depression Inventory II, BAI Beck Anxiety Inventory